Experimental allergic encephalomyelitis (4E) is a well-established model of human multiple sclerosis that is commonly used to evaluate the possible effectiveness of new treatments in this disease. Extracorporeal photochemotherapy (ECP) is an immunomodulating procedure currently used in several non-neurological diseases that, like multiple sclerosis, are likely to be due to T-cell-mediated autoimmunity. in this study we examined the effect of ECP using the EAE paradigm in the Lewis rat. In our model, ECP induced a significant modulation in peripheral blood T-cell distribution, changes which are typical of EAE. Remarkably this effect was closely correlated with the clinical and pathological results, which showed reduced severity of the disease in the ECP-treated EAE animals vs, the EAE alone rats. We conclude that ECP induces modifications in the immunological events that occur during the course of EAE in rats, thus giving support to the hypothesis that it could be used in the treatment of multiple sclerosis.

Cavaletti, G., Perseghin, P., Buscemi, F., Dassi, M., Oggioni, N., Sala, F., et al. (2001). Immunomodulating effects of extracorporeal photochemotherapy in rat experimental allergic encephalomyelitis. INTERNATIONAL JOURNAL OF TISSUE REACTIONS, 23(1), 21-31.

Immunomodulating effects of extracorporeal photochemotherapy in rat experimental allergic encephalomyelitis

CAVALETTI, GUIDO ANGELO;OGGIONI, NORBERTO;FRATTOLA, LODOVICO;TREDICI, GIOVANNI
2001

Abstract

Experimental allergic encephalomyelitis (4E) is a well-established model of human multiple sclerosis that is commonly used to evaluate the possible effectiveness of new treatments in this disease. Extracorporeal photochemotherapy (ECP) is an immunomodulating procedure currently used in several non-neurological diseases that, like multiple sclerosis, are likely to be due to T-cell-mediated autoimmunity. in this study we examined the effect of ECP using the EAE paradigm in the Lewis rat. In our model, ECP induced a significant modulation in peripheral blood T-cell distribution, changes which are typical of EAE. Remarkably this effect was closely correlated with the clinical and pathological results, which showed reduced severity of the disease in the ECP-treated EAE animals vs, the EAE alone rats. We conclude that ECP induces modifications in the immunological events that occur during the course of EAE in rats, thus giving support to the hypothesis that it could be used in the treatment of multiple sclerosis.
Articolo in rivista - Articolo scientifico
photopheresis
English
2001
23
1
21
31
none
Cavaletti, G., Perseghin, P., Buscemi, F., Dassi, M., Oggioni, N., Sala, F., et al. (2001). Immunomodulating effects of extracorporeal photochemotherapy in rat experimental allergic encephalomyelitis. INTERNATIONAL JOURNAL OF TISSUE REACTIONS, 23(1), 21-31.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/55642
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