The discovery of novel anti-cancer drugs targeting anaplastic lymphoma kinase (ALK), an oncogenic tyrosine kinase, raises the need for in vitro assays suitable for screening compounds for ALK inhibition. To this aim we have developed and optimized an ALK-specific enzyme-linked immunosorbent assay that employs a novel ALK peptide substrate and purified ALK kinase domain.

Gunby, R., Tartari, C., Porchia, F., Donella Deana, A., Scapozza, L., GAMBACORTI PASSERINI, C. (2005). An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase. HAEMATOLOGICA, 90(7), 988-990.

An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase

GAMBACORTI PASSERINI, CARLO
2005

Abstract

The discovery of novel anti-cancer drugs targeting anaplastic lymphoma kinase (ALK), an oncogenic tyrosine kinase, raises the need for in vitro assays suitable for screening compounds for ALK inhibition. To this aim we have developed and optimized an ALK-specific enzyme-linked immunosorbent assay that employs a novel ALK peptide substrate and purified ALK kinase domain.
Articolo in rivista - Articolo scientifico
ALCL; ALK; kinase assay; inhibitor screening
English
2005
90
7
988
990
none
Gunby, R., Tartari, C., Porchia, F., Donella Deana, A., Scapozza, L., GAMBACORTI PASSERINI, C. (2005). An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase. HAEMATOLOGICA, 90(7), 988-990.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/549
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