Aquaporins (AQPs) are an ubiquitous family of proteins characterized by sequence similarity and the presence of two NPA (Asp-Pro-Ala) motifs. At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQPO, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12). The genomic, structural, and functional aspects of this family are briefly described. In particular, proteomic approaches to identify and characterize the most studied AQPs, mainly through SDS-PAGE followed by MS analysis, are discussed. Moreover, the clinical importance of the best studied aquaporin (AQP1) in human diseases is also provided. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
Magni, F., Sarto, C., Ticozzi, D., Soldi, M., Bosso, N., Mocarelli, P., et al. (2006). Proteomic knowledge of human aquaporins. PROTEOMICS, 6(20), 5637-5649 [10.1002/pmic.200600212].
Proteomic knowledge of human aquaporins
MAGNI, FULVIO;MOCARELLI, PAOLO;KIENLE, MARZIA DONATELLA
2006
Abstract
Aquaporins (AQPs) are an ubiquitous family of proteins characterized by sequence similarity and the presence of two NPA (Asp-Pro-Ala) motifs. At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQPO, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12). The genomic, structural, and functional aspects of this family are briefly described. In particular, proteomic approaches to identify and characterize the most studied AQPs, mainly through SDS-PAGE followed by MS analysis, are discussed. Moreover, the clinical importance of the best studied aquaporin (AQP1) in human diseases is also provided. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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