Pulmonary inflammation often results in expression of the class II major histocompatibility complex (MHCII) by both professional antigen-presenting cells (APCs; histiocytes and lymphocytes) and non-professional APCs (respiratory epithelium and endothelium). In this study lesions from 17 cases of bovine chronic pneumonia, associated with Mycoplasma bovis infection, were examined immunohistochemically for M. bovis antigen and MHCII expression. Ten cases of chronic necrosuppurative bronchopneumonia (NBP) were shown to be characterized by abundant perinecrotic M. bovis antigen associated with scant MHCII expression by degenerate leucocytes. Seven cases of chronic catarrhal bronchointerstitial pneumonia (CBP) showed prominent MHCII expression by both professional APCs and respiratory epithelium, in the absence of intralesional M. bovis immunolabelling. The results suggest that prominent MHCII expression by both professional and non-professional APCs plays a role in the pathogenesis of M. bovis-induced CBP. Conversely, the role of MHCII expression in necrosuppurative foci typical of M. bovis-associated NBP can be considered negligible.

Radaelli, E., Luini, M., Domeneghini, C., Loria, G., Recordati, C., Radaelli, P., et al. (2009). Expression of Class II Major Histocompatibility Complex Molecules in Chronic Pulmonary Mycoplasma bovis Infection in Cattle. JOURNAL OF COMPARATIVE PATHOLOGY, 140(2-3), 198-202 [10.1016/j.jcpa.2008.10.008].

Expression of Class II Major Histocompatibility Complex Molecules in Chronic Pulmonary Mycoplasma bovis Infection in Cattle

RADAELLI, PAOLO;
2009

Abstract

Pulmonary inflammation often results in expression of the class II major histocompatibility complex (MHCII) by both professional antigen-presenting cells (APCs; histiocytes and lymphocytes) and non-professional APCs (respiratory epithelium and endothelium). In this study lesions from 17 cases of bovine chronic pneumonia, associated with Mycoplasma bovis infection, were examined immunohistochemically for M. bovis antigen and MHCII expression. Ten cases of chronic necrosuppurative bronchopneumonia (NBP) were shown to be characterized by abundant perinecrotic M. bovis antigen associated with scant MHCII expression by degenerate leucocytes. Seven cases of chronic catarrhal bronchointerstitial pneumonia (CBP) showed prominent MHCII expression by both professional APCs and respiratory epithelium, in the absence of intralesional M. bovis immunolabelling. The results suggest that prominent MHCII expression by both professional and non-professional APCs plays a role in the pathogenesis of M. bovis-induced CBP. Conversely, the role of MHCII expression in necrosuppurative foci typical of M. bovis-associated NBP can be considered negligible.
Articolo in rivista - Articolo scientifico
bacterial infection; cattle; MHCII; Mycoplasma bovis; pneumonia
English
2009
140
2-3
198
202
none
Radaelli, E., Luini, M., Domeneghini, C., Loria, G., Recordati, C., Radaelli, P., et al. (2009). Expression of Class II Major Histocompatibility Complex Molecules in Chronic Pulmonary Mycoplasma bovis Infection in Cattle. JOURNAL OF COMPARATIVE PATHOLOGY, 140(2-3), 198-202 [10.1016/j.jcpa.2008.10.008].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/5056
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