The role of alcohol intake in the risk for multiple myeloma (MM) is unclear, although some recent findings suggest an inverse relationship. To summarize the information on the topic, we carried out a systematic review and a dose-risk meta-analysis of published data. Through the literature search until August 2013, we identified 18 studies, eight case-control and 10 cohort studies, carried out in a total of 5694 MM patients. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and we carried out a dose-risk analysis using a class of nonlinear random-effects meta-regression models. The relative risk for alcohol drinkers versus non/occasional drinkers was 0.97 [95% confidence interval (CI), 0.85-1.10] overall, 0.96 (95% CI, 0.74-1.24) among case-control studies, and 1.00 (95% CI, 0.89-1.13) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.96 (95% CI, 0.81-1.13) for light (i.e. ≤1 drink/day) and 0.89 (95% CI, 0.74-1.07) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinkers. The dose-risk analysis revealed a model-based MM risk reduction of about 15% at two to four drinks/day (i.e. 25-50 g of ethanol). The present meta-analysis of published data found no strong association between alcohol drinking and MM risk, although a modest favorable effect emerged for moderate-to-heavy alcohol drinkers. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Rota, M., Porta, L., Pelucchi, C., Negri, E., Bagnardi, V., Bellocco, R., et al. (2014). Alcohol drinking and multiple myeloma risk - A systematic review and meta-analysis of the dose-risk relationship. EUROPEAN JOURNAL OF CANCER PREVENTION, 23(2), 113-121 [10.1097/CEJ.0000000000000001].

Alcohol drinking and multiple myeloma risk - A systematic review and meta-analysis of the dose-risk relationship

ROTA, MATTEO;Porta, L;BAGNARDI, VINCENZO;BELLOCCO, RINO;CORRAO, GIOVANNI;
2014

Abstract

The role of alcohol intake in the risk for multiple myeloma (MM) is unclear, although some recent findings suggest an inverse relationship. To summarize the information on the topic, we carried out a systematic review and a dose-risk meta-analysis of published data. Through the literature search until August 2013, we identified 18 studies, eight case-control and 10 cohort studies, carried out in a total of 5694 MM patients. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and we carried out a dose-risk analysis using a class of nonlinear random-effects meta-regression models. The relative risk for alcohol drinkers versus non/occasional drinkers was 0.97 [95% confidence interval (CI), 0.85-1.10] overall, 0.96 (95% CI, 0.74-1.24) among case-control studies, and 1.00 (95% CI, 0.89-1.13) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.96 (95% CI, 0.81-1.13) for light (i.e. ≤1 drink/day) and 0.89 (95% CI, 0.74-1.07) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinkers. The dose-risk analysis revealed a model-based MM risk reduction of about 15% at two to four drinks/day (i.e. 25-50 g of ethanol). The present meta-analysis of published data found no strong association between alcohol drinking and MM risk, although a modest favorable effect emerged for moderate-to-heavy alcohol drinkers. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Articolo in rivista - Articolo scientifico
alcohol drinking; dose–risk relation; meta-analysis; multiple myeloma; systematic review
English
2014
23
2
113
121
none
Rota, M., Porta, L., Pelucchi, C., Negri, E., Bagnardi, V., Bellocco, R., et al. (2014). Alcohol drinking and multiple myeloma risk - A systematic review and meta-analysis of the dose-risk relationship. EUROPEAN JOURNAL OF CANCER PREVENTION, 23(2), 113-121 [10.1097/CEJ.0000000000000001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/49967
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