Integrin receptors mediate adhesion of the cell to the extracellular matrix and thereby regulate cell motility, proliferation, differentiation and apoptosis. These processes are frequently accompanied by alterations in ion flow. Recent evidence suggests that integrins can regulate ion channels and form macromolecular complexes, thus contributing to the localization of the channel onto the plasma membrane. The integrin-channel complex regulates downstream signaling proteins, such as tyrosine kinases and GTPases. This process could occur in plasma membrane microdomains, such as caveolae. It seems that ion channels sometimes transmit their signals through conformational coupling, instead of change in ion fluxes. Finally, the channel protein is not merely a final target, because it often feeds back by controlling integrin activation and/or expression. These findings have important implications for the physiology of normal and neoplastic cells and suggest interesting perspectives for studies of synaptic plasticity. © 2006 Elsevier Ltd. All rights reserved.

Arcangeli, A., Becchetti, A. (2006). Complex functional interaction between integrin receptors and ion channels. TRENDS IN CELL BIOLOGY, 16(12), 631-639 [10.1016/j.tcb.2006.10.003].

Complex functional interaction between integrin receptors and ion channels

BECCHETTI, ANDREA
2006

Abstract

Integrin receptors mediate adhesion of the cell to the extracellular matrix and thereby regulate cell motility, proliferation, differentiation and apoptosis. These processes are frequently accompanied by alterations in ion flow. Recent evidence suggests that integrins can regulate ion channels and form macromolecular complexes, thus contributing to the localization of the channel onto the plasma membrane. The integrin-channel complex regulates downstream signaling proteins, such as tyrosine kinases and GTPases. This process could occur in plasma membrane microdomains, such as caveolae. It seems that ion channels sometimes transmit their signals through conformational coupling, instead of change in ion fluxes. Finally, the channel protein is not merely a final target, because it often feeds back by controlling integrin activation and/or expression. These findings have important implications for the physiology of normal and neoplastic cells and suggest interesting perspectives for studies of synaptic plasticity. © 2006 Elsevier Ltd. All rights reserved.
Articolo in rivista - Articolo scientifico
extracellular matrix, adhesion, membrane complex, ion flux, integrins, channels, signaling
English
2006
16
12
631
639
none
Arcangeli, A., Becchetti, A. (2006). Complex functional interaction between integrin receptors and ion channels. TRENDS IN CELL BIOLOGY, 16(12), 631-639 [10.1016/j.tcb.2006.10.003].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/489
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