Diagnostic imaging plays a relevant role in the care of patients with breast cancer (BC). Positron Emission Tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (FDG) has been widely proven to be a clinical tool suitable for BC detection and staging in which the glucose analog supplies metabolic information about the tumor. A limited number of studies, sometimes controversial, describe possible associations between FDG uptake and single nucleotide polymorphisms (SNPs). For this reason this field has to be explored and clarified. We investigated the association of SNPs in GLUT1, HIF-1a, EPAS1, APEX1, VEGFA and MTHFR genes with the FDG uptake in BC.
Bravatà, V., Stefano, A., Cammarata, F., Minafra, L., Russo, G., Nicolosi, S., et al. (2013). Genotyping analysis and (18)FDG uptake in breast cancer patients: a preliminary research. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 32(1), 23 [10.1186/1756-9966-32-23].
Genotyping analysis and (18)FDG uptake in breast cancer patients: a preliminary research
GILARDI, MARIA CARLA;MESSA, MARIA CRISTINA
2013
Abstract
Diagnostic imaging plays a relevant role in the care of patients with breast cancer (BC). Positron Emission Tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (FDG) has been widely proven to be a clinical tool suitable for BC detection and staging in which the glucose analog supplies metabolic information about the tumor. A limited number of studies, sometimes controversial, describe possible associations between FDG uptake and single nucleotide polymorphisms (SNPs). For this reason this field has to be explored and clarified. We investigated the association of SNPs in GLUT1, HIF-1a, EPAS1, APEX1, VEGFA and MTHFR genes with the FDG uptake in BC.
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