The aim of the present study was to comprehensively evaluate systemic and local inflammation as well as progression of vascular inflammation in normal and mechanically injured vessels in a large animal model of mild hypercholesterolemia. Our aim was also to test the effect of high-dose statin treatment on these processes.
Busnelli, M., Manzini, S., Froio, A., Vargiolu, A., Cerrito, M., Smolenski, R., et al. (2013). Diet Induced Mild Hypercholesterolemia in Pigs: Local and Systemic Inflammation, Effects on Vascular Injury - Rescue by High-Dose Statin Treatment. PLOS ONE, 8(11), e80588 [10.1371/journal.pone.0080588].
Diet Induced Mild Hypercholesterolemia in Pigs: Local and Systemic Inflammation, Effects on Vascular Injury - Rescue by High-Dose Statin Treatment
BUSNELLI, MARCO;MANZINI, STEFANO;FROIO, ALBERTO;VARGIOLU, ALESSIA;CERRITO, MARIA GRAZIA;SMOLENSKI, RYSZARD TOMASZ;CINTI, ALESSANDRO;LEONE, BIAGIO EUGENIO;BIASI, GIORGIO MARIA;GIOVANNONI, ROBERTO;LAVITRANO, MARIALUISA
2013
Abstract
The aim of the present study was to comprehensively evaluate systemic and local inflammation as well as progression of vascular inflammation in normal and mechanically injured vessels in a large animal model of mild hypercholesterolemia. Our aim was also to test the effect of high-dose statin treatment on these processes.
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