Scopolamine, a muscarinic antagonist, impairs memory performance in both humans and animals. In this study, repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers whilst performing auditory verbal memory tasks, before and after the administration of scopolamine (0.4 mg s.c.) or placebo. Compared to placebo, scopolamine increased blood flow in the lateral occipital cortex bilaterally and the left orbitofrontal region. Scopolamine decreased rCBF in the region of the right thalamus, the precuneus and the right and left lateral premotor areas. Scopolamine attenuated memory-task-induced increases of rCBF in the left and right prefrontal cortex and the right anterior cingulate region. These data suggest that acute blockade of cholinergic neurotransmission affects diverse brain areas, including components of the visual and motor systems, and, in addition, modulates memory task activations at distinct points in a distributed network for memory function

Grasby, P., Frith, C., Paulesu, E., Friston, K., Frackowiak, R., Dolan, R. (1995). The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task. EXPERIMENTAL BRAIN RESEARCH, 104(2), 337-348 [10.1007/BF00242019].

The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task

PAULESU, ERALDO;
1995

Abstract

Scopolamine, a muscarinic antagonist, impairs memory performance in both humans and animals. In this study, repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers whilst performing auditory verbal memory tasks, before and after the administration of scopolamine (0.4 mg s.c.) or placebo. Compared to placebo, scopolamine increased blood flow in the lateral occipital cortex bilaterally and the left orbitofrontal region. Scopolamine decreased rCBF in the region of the right thalamus, the precuneus and the right and left lateral premotor areas. Scopolamine attenuated memory-task-induced increases of rCBF in the left and right prefrontal cortex and the right anterior cingulate region. These data suggest that acute blockade of cholinergic neurotransmission affects diverse brain areas, including components of the visual and motor systems, and, in addition, modulates memory task activations at distinct points in a distributed network for memory function
Articolo in rivista - Articolo scientifico
Scopolamine; rCBF; memory
English
1995
104
2
337
348
none
Grasby, P., Frith, C., Paulesu, E., Friston, K., Frackowiak, R., Dolan, R. (1995). The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task. EXPERIMENTAL BRAIN RESEARCH, 104(2), 337-348 [10.1007/BF00242019].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/45498
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