In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells. Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Mazzucchelli, S., Colombo, M., Verderio, P., Rozek, E., Andreata, F., Galbiati, E., et al. (2013). Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells. ANGEWANDTE CHEMIE, 52(11), 3121-3125 [10.1002/anie.201209662].
Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells
MAZZUCCHELLI, SERENA;COLOMBO, MIRIAM;VERDERIO, PAOLO;Andreata, F;GALBIATI, ELISABETTA;TORTORA, PAOLO;PROSPERI, DAVIDE
2013
Abstract
In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells. Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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