The loss of myelin sheath which surrounds a nerve fiber is usually quantified by the visual scoring of unaltered axons and the measuring of cross-sectional areas. An attempt at the automated classification of morphological alterations affecting de-myelinated nerve fibers is presented herewith. Thin cross-sections of rat sciatic nerves, both unaltered (controls) and affected by constriction (Bennet - Xie ligature) have been stained and imaged by optical microscopy. Image processing has included: spatial differentiation, fractal analysis, and Fourier transformation followed by non-linear filtering. A set of quantitative morphological descriptors has been derived, then submitted to multivariate statistical analysis, the goal being discrimination between control and injured nerve bundles. The first discrimination results are described.

Crosta, G., Urani, C., Bonfanti, P., Colombo, A., Costa, B., Fumarola, L., et al. (2003). Classificazione morfologica della degenerazione di fibre nervose mieliniche nella patologia neuropatica. In Abstracts del 64° convegno UZI (pp.140).

Classificazione morfologica della degenerazione di fibre nervose mieliniche nella patologia neuropatica

CROSTA, GIOVANNI FRANCO FILIPPO;URANI, CHIARA;BONFANTI, PATRIZIA;COLOMBO, ANITA EMILIA;
2003

Abstract

The loss of myelin sheath which surrounds a nerve fiber is usually quantified by the visual scoring of unaltered axons and the measuring of cross-sectional areas. An attempt at the automated classification of morphological alterations affecting de-myelinated nerve fibers is presented herewith. Thin cross-sections of rat sciatic nerves, both unaltered (controls) and affected by constriction (Bennet - Xie ligature) have been stained and imaged by optical microscopy. Image processing has included: spatial differentiation, fractal analysis, and Fourier transformation followed by non-linear filtering. A set of quantitative morphological descriptors has been derived, then submitted to multivariate statistical analysis, the goal being discrimination between control and injured nerve bundles. The first discrimination results are described.
abstract + poster
chronic constriction injury; sciatic nerve; nerve ligature; mylein sheath; de-myelinated axons; morphological alterations; quantitative morphology; image filtering; image understanding; image classification
Classificazione morfologica degenerazione fibre mieliniche, neuropatia
Italian
Congresso Unione Zoologica Italiana
2003
Abstracts del 64° convegno UZI
2003
140
none
Crosta, G., Urani, C., Bonfanti, P., Colombo, A., Costa, B., Fumarola, L., et al. (2003). Classificazione morfologica della degenerazione di fibre nervose mieliniche nella patologia neuropatica. In Abstracts del 64° convegno UZI (pp.140).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/39237
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