Chronic activation of the renin-angiotensin system (RAS) plays an important role in the pathogenesis of heart failure. Increasing evidence indicates that other than the circulating RAS, a local RAS exists in several tissues, including the heart. The present study was carried out to quantify cardiac, renal, and pulmonary mRNA levels of renin, angiotensin-converting enzyme (ACE), and types 1 and 2 angiotensin II receptors (AT-1 and AT-2), in rats with different severities of heart failure.

Pieruzzi, F., Abassi, Z., Keiser, H. (1995). Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure. CIRCULATION, 92(10), 3105-3112 [10.1161/01.CIR.92.10.3105].

Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure

PIERUZZI, FEDERICO UMBERTO EMILIO GUGLIE;
1995

Abstract

Chronic activation of the renin-angiotensin system (RAS) plays an important role in the pathogenesis of heart failure. Increasing evidence indicates that other than the circulating RAS, a local RAS exists in several tissues, including the heart. The present study was carried out to quantify cardiac, renal, and pulmonary mRNA levels of renin, angiotensin-converting enzyme (ACE), and types 1 and 2 angiotensin II receptors (AT-1 and AT-2), in rats with different severities of heart failure.
Articolo in rivista - Articolo scientifico
Renin; Animals; Heart Failure; Peptidyl-Dipeptidase A; Gene Expression; Receptors, Angiotensin; Angiotensin II; RNA, Messenger; Rats; Polymerase Chain Reaction; Rats, Sprague-Dawley; Blotting, Western; Lung; Renin-Angiotensin System; Kidney; Male; Myocardium
English
15-nov-1995
92
10
3105
3112
none
Pieruzzi, F., Abassi, Z., Keiser, H. (1995). Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure. CIRCULATION, 92(10), 3105-3112 [10.1161/01.CIR.92.10.3105].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/39166
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