IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishArterial hypertension, dyslipidemia, alterations in glucose metabolism and fatty liver, either alone or in association, are frequently observed in obese children and may seriously jeopardize their health. For obesity to develop, an excessive intake of energy-bearing macronutrients is required; however, ample evidence suggests that fructose may promote the development of obesity and/or metabolic alterations, independently of its energy intake. Fructose consumption is particularly high among children, because they do not have the perception, and more importantly, neither do their parents, that high fructose intake is potentially dangerous. In fact, while this sugar is erroneously viewed favorably as a natural nutrient, its excessive intake can actually cause adverse cardio-metabolic alterations. Fructose induces the release of pro-inflammatory cytokines, and reduces the production of anti-atherosclerotic cytokines, such as adiponectin. Furthermore, by interacting with hunger and satiety control systems, particularly by inducing leptin resistance, it leads to increased caloric intake. Fructose, directly or through its metabolites, promotes the development of obesity, arterial hypertension, dyslipidemia, glucose intolerance and fatty liver. This review aims to highlight the mechanisms by which the early and excessive consumption of fructose may contribute to the development of a variety of cardiometabolic risk factors in children, thus representing a potential danger to their health. It will also describe the main clinical trials performed in children and adolescents that have evaluated the clinical effects of excessive intake of fructose-containing drinks and food, with particular attention to the effects on blood pressure. Finally, we will discuss the effectiveness of measures that can be taken to reduce the intake of this sugar.
Giussani, M., Lieti, G., Orlando, A., Parati, G., & Genovesi, S. (2022). Fructose Intake, Hypertension and Cardiometabolic Risk Factors in Children and Adolescents: From Pathophysiology to Clinical Aspects. A Narrative Review. FRONTIERS IN MEDICINE, 9 [10.3389/fmed.2022.792949].
| Citazione: | Giussani, M., Lieti, G., Orlando, A., Parati, G., & Genovesi, S. (2022). Fructose Intake, Hypertension and Cardiometabolic Risk Factors in Children and Adolescents: From Pathophysiology to Clinical Aspects. A Narrative Review. FRONTIERS IN MEDICINE, 9 [10.3389/fmed.2022.792949]. | |
| Titolo: | Fructose Intake, Hypertension and Cardiometabolic Risk Factors in Children and Adolescents: From Pathophysiology to Clinical Aspects. A Narrative Review | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Carattere della pubblicazione: | Scientifica | |
| Autori: | GENOVESI, SIMONETTA CARLA (Corresponding) | |
| Data di pubblicazione: | 2022 | |
| Autori: | Giussani, M; Lieti, G; Orlando, A; Parati, G; Genovesi, S | |
| Numero degli autori: | 5 | |
| Lingua: | English | |
| Rivista: | FRONTIERS IN MEDICINE | |
| Nazione editore: | Switzerland | |
| Editore: | Frontiers Media S.A. | |
| Supporto: | Elettronico | |
| Revisione (peer review): | Esperti anonimi | |
| Stato di pubblicazione: | Pubblicato | |
| Volume: | 9 | |
| Numero dell’articolo: | 792949 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3389/fmed.2022.792949 | |
| Full-text (pubblici): | none | |
| Tipologia: | Articolo su rivista | |
| Tipologia MIUR: | 262 | |
| Codice identificativo Scopus: | 2-s2.0-85128748162 | |
| Codice identificativo ISI: | WOS:000791677500001 | |
| Codice identificativo Pubmed: | 35492316 | |
| Abstract: | Arterial hypertension, dyslipidemia, alterations in glucose metabolism and fatty liver, either al...one or in association, are frequently observed in obese children and may seriously jeopardize their health. For obesity to develop, an excessive intake of energy-bearing macronutrients is required; however, ample evidence suggests that fructose may promote the development of obesity and/or metabolic alterations, independently of its energy intake. Fructose consumption is particularly high among children, because they do not have the perception, and more importantly, neither do their parents, that high fructose intake is potentially dangerous. In fact, while this sugar is erroneously viewed favorably as a natural nutrient, its excessive intake can actually cause adverse cardio-metabolic alterations. Fructose induces the release of pro-inflammatory cytokines, and reduces the production of anti-atherosclerotic cytokines, such as adiponectin. Furthermore, by interacting with hunger and satiety control systems, particularly by inducing leptin resistance, it leads to increased caloric intake. Fructose, directly or through its metabolites, promotes the development of obesity, arterial hypertension, dyslipidemia, glucose intolerance and fatty liver. This review aims to highlight the mechanisms by which the early and excessive consumption of fructose may contribute to the development of a variety of cardiometabolic risk factors in children, thus representing a potential danger to their health. It will also describe the main clinical trials performed in children and adolescents that have evaluated the clinical effects of excessive intake of fructose-containing drinks and food, with particular attention to the effects on blood pressure. Finally, we will discuss the effectiveness of measures that can be taken to reduce the intake of this sugar. | |
| Parole Chiave (Inglese): | cardio-metabolic risk factors; children; fructose; hypertension; obesity; sugar-sweetened beverages; | |
| Data Ahead of Print: | 2022-04-12 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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