Spectral data and thermodynamic calculations of adducts of purines (guanine, adenine), or pyrimidines (thymine, uracil) with acrylic monomers (acrylonitrile, ethyl acrylate and ethyl crotonate) are reported. Purine adducts derive from attack at N-7 and N-9, and pyrimidine adducts derive from attack at N-1. Acrylonitrile forms also N-1, N-3 bis adducts with pyrimidines. Structural assignment was by H-1 and C-13 NMR and using COSY-RELAY and NOE effects. Force-field calculations indicated the most stable conformations of the reaction products
Crippa, S., DI GENNARO, P., Lucini, R., Orlandi, M., Rindone, B. (1993). Characterization of adducts of nucleic bases and acrylic-monomers. GAZZETTA CHIMICA ITALIANA, 123(4), 197-203.
Characterization of adducts of nucleic bases and acrylic-monomers
DI GENNARO, PATRIZIA;ORLANDI, MARCO EMILIO;RINDONE, BRUNO
1993
Abstract
Spectral data and thermodynamic calculations of adducts of purines (guanine, adenine), or pyrimidines (thymine, uracil) with acrylic monomers (acrylonitrile, ethyl acrylate and ethyl crotonate) are reported. Purine adducts derive from attack at N-7 and N-9, and pyrimidine adducts derive from attack at N-1. Acrylonitrile forms also N-1, N-3 bis adducts with pyrimidines. Structural assignment was by H-1 and C-13 NMR and using COSY-RELAY and NOE effects. Force-field calculations indicated the most stable conformations of the reaction products
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