We report a subtype of immune-mediated encephalitis associated with COVID-19, which closely mimics acute-onset sporadic Creutzfeldt-Jakob disease. A 64-year-old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS-CoV-2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14-3-3 protein. RT-QuIC analysis was negative. High levels of pro-inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6-month follow-up.

Beretta, S., Stabile, A., Balducci, C., Difrancesco, J., Patruno, A., Rona, R., et al. (2021). COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 8(12), 2314-2318 [10.1002/acn3.51479].

COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease

Beretta, Simone
;
Stabile, Andrea;Balducci, Claudia;DiFrancesco, Jacopo C.;Capraro, Cristina;Moda, Fabio;Citerio, Giuseppe;Foti, Giuseppe;Ferrarese, Carlo
2021

Abstract

We report a subtype of immune-mediated encephalitis associated with COVID-19, which closely mimics acute-onset sporadic Creutzfeldt-Jakob disease. A 64-year-old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS-CoV-2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14-3-3 protein. RT-QuIC analysis was negative. High levels of pro-inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6-month follow-up.
Articolo in rivista - Articolo scientifico
COVID‐19; encephalitsi;
English
26-nov-2021
2021
8
12
2314
2318
reserved
Beretta, S., Stabile, A., Balducci, C., Difrancesco, J., Patruno, A., Rona, R., et al. (2021). COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 8(12), 2314-2318 [10.1002/acn3.51479].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/337290
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