The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly induced by toxic species formed by the amyloid beta (Aβ) peptide; therefore, therapeutics aimed at reducing Aβ toxicity could be of clinical use for treatment of AD. Liposomes are suitable vehicles for therapeutic agents and imaging probes, and a promising way of targeting the various Aβ forms. We tested liposomes functionalized with phosphatidic acid, cardiolipin, or GM1 ganglioside, previously shown to have high Aβ-binding capacity. Mimicking Aβ-induced toxicity in mouse neuroblastoma cell lines, combined with administration of cell viability-modulating agents, we observed that functionalized liposomes rescued cell viability to different extents. We also detected rescue of the imbalance of GSK-3β and PP2A activity, and reduction in tau phosphorylation. Thus, these liposomes appear particularly suitable for implementing further therapeutic strategies for AD.

Bereczki, E., Re, F., Masserini, M., Winblad, B., Pei, J. (2011). Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells. NANOMEDICINE, 7(5), 560-571 [10.1016/j.nano.2011.05.009].

Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells

Re, F;Masserini, ME;
2011

Abstract

The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly induced by toxic species formed by the amyloid beta (Aβ) peptide; therefore, therapeutics aimed at reducing Aβ toxicity could be of clinical use for treatment of AD. Liposomes are suitable vehicles for therapeutic agents and imaging probes, and a promising way of targeting the various Aβ forms. We tested liposomes functionalized with phosphatidic acid, cardiolipin, or GM1 ganglioside, previously shown to have high Aβ-binding capacity. Mimicking Aβ-induced toxicity in mouse neuroblastoma cell lines, combined with administration of cell viability-modulating agents, we observed that functionalized liposomes rescued cell viability to different extents. We also detected rescue of the imbalance of GSK-3β and PP2A activity, and reduction in tau phosphorylation. Thus, these liposomes appear particularly suitable for implementing further therapeutic strategies for AD.
Articolo in rivista - Articolo scientifico
liposomes, neuroblastoma cells;
English
2011
7
5
560
571
none
Bereczki, E., Re, F., Masserini, M., Winblad, B., Pei, J. (2011). Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells. NANOMEDICINE, 7(5), 560-571 [10.1016/j.nano.2011.05.009].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/29215
Citazioni
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 28
Social impact