We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Mura, M., Lee, Y., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., et al. (2019). Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. STEM CELL RESEARCH, 37 [10.1016/j.scr.2019.101431].

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Crotti L;
2019

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).
Articolo in rivista - Articolo scientifico
human induced pluripotent stem cell, long qt syndrome, cardiac potassium channel
English
2019
37
101431
open
Mura, M., Lee, Y., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., et al. (2019). Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. STEM CELL RESEARCH, 37 [10.1016/j.scr.2019.101431].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/281509
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