Aim: To simulate effects of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy on the patients' characteristics and post orthotopic liver transplantation (OLT) outcome. Materials & methods: The United Network for Organ Sharing database was used to identify patients with hepatocellular carcinoma who were listed for OLT 2002-2014. All patients (actual group) versus simulated group with new 6-month delay in assigning Model for End-Stage Liver Disease score exception and Model for End-Stage Liver Disease exception cap of 34 were compared. Results & conclusion: With the new policy, 7,745 (30.4%) of the transplanted patients would have received a delayed transplantation or not be transplanted. The simulated group also showed significantly higher mean overall survival after OLT (p < 0.002) and received more locoreginal treatments (p < 0.001).

Kokabi, N., Nezami, N., Xing, M., Ludwig, J., Strazzabosco, M., Kim, H. (2019). Modeling of implementation of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy for patients with hepatocellular carcinoma. JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 8(12), 993-1002 [10.2217/cer-2019-0076].

Modeling of implementation of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy for patients with hepatocellular carcinoma

Strazzabosco M.;
2019

Abstract

Aim: To simulate effects of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy on the patients' characteristics and post orthotopic liver transplantation (OLT) outcome. Materials & methods: The United Network for Organ Sharing database was used to identify patients with hepatocellular carcinoma who were listed for OLT 2002-2014. All patients (actual group) versus simulated group with new 6-month delay in assigning Model for End-Stage Liver Disease score exception and Model for End-Stage Liver Disease exception cap of 34 were compared. Results & conclusion: With the new policy, 7,745 (30.4%) of the transplanted patients would have received a delayed transplantation or not be transplanted. The simulated group also showed significantly higher mean overall survival after OLT (p < 0.002) and received more locoreginal treatments (p < 0.001).
Articolo in rivista - Articolo scientifico
hepatocellular carcinoma, liver transplantation, new policy, Organ Procurement and Transplantation Network, survival rate, United Network for Organ Sharing
English
2019
8
12
993
1002
none
Kokabi, N., Nezami, N., Xing, M., Ludwig, J., Strazzabosco, M., Kim, H. (2019). Modeling of implementation of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy for patients with hepatocellular carcinoma. JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 8(12), 993-1002 [10.2217/cer-2019-0076].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/280511
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