(Chemical Equation Presented) Condensation of squaric acid with a number of differently substituted 2-pyrrolyl derivatives afforded three new classes of squaraines. Their sharp and intense absorption bands in the biological window (700-900 nm), inherent singlet oxygen generation capabilities, together with proper functionalization allowing good water solubility make them suitable candidates as new non-porphyrinic singlet oxygen photosensitizers for photodynamic therapy (PDT). © 2005 American Chemical Society.
Beverina, L., Abbotto, A., Landenna, M., Cerminara, M., Tubino, R., Meinardi, F., et al. (2005). New Pi-Extended Water-Soluble Squaraines as Singlet Oxygen Generators. ORGANIC LETTERS, 7(19), 4257-4260 [10.1021/ol0516871].
New Pi-Extended Water-Soluble Squaraines as Singlet Oxygen Generators
BEVERINA, LUCA;ABBOTTO, ALESSANDRO;TUBINO, RICCARDO;MEINARDI, FRANCESCO;PAGANI, GIORGIO ALBERTO
2005
Abstract
(Chemical Equation Presented) Condensation of squaric acid with a number of differently substituted 2-pyrrolyl derivatives afforded three new classes of squaraines. Their sharp and intense absorption bands in the biological window (700-900 nm), inherent singlet oxygen generation capabilities, together with proper functionalization allowing good water solubility make them suitable candidates as new non-porphyrinic singlet oxygen photosensitizers for photodynamic therapy (PDT). © 2005 American Chemical Society.
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