Novel, conformationally constrained 1,4-benzodiazepine-2,5-diones containing both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric scaffolds; preliminary biological evaluation as GABA<sub>A</sub> receptor ligands is reported. © Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Araujo, A., Nicotra, F., Airoldi, C., Costa, B., Giagnoni, G., Fumagalli, P., et al. (2008). Synthesis and biological evaluation of novel rigid 1,4-benzodiazepine-2,5-dione chimeric scaffolds. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008(4), 635-639 [10.1002/ejoc.200700952].
Synthesis and biological evaluation of novel rigid 1,4-benzodiazepine-2,5-dione chimeric scaffolds
NICOTRA, FRANCESCO;AIROLDI, CRISTINA;COSTA, BARBARA SIMONA;GIAGNONI, GABRIELLA;FUMAGALLI, PIETRO;CIPOLLA, LAURA FRANCESCA
2008
Abstract
Novel, conformationally constrained 1,4-benzodiazepine-2,5-diones containing both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric scaffolds; preliminary biological evaluation as GABAA receptor ligands is reported. © Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
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