Inconsistent results on the relationship between alcohol drinking and prostate cancer have been found. In order to provide a definite quantification of the dose-risk relation, we investigated the risk of prostate cancer at different levels of alcohol consumption, by conducting a meta-analysis of epidemiological studies. We performed a literature search using PubMed of all case-control and cohort studies published as original articles in English up to December 2010. We identified 50 case-control and 22 cohort studies, including a total of 52 899 prostate cancer cases. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates. We performed a dose-risk analysis using nonlinear random-effects meta-regression models. The overall relative risk for any alcohol drinking compared with non/occasional drinking was 1.06 [95% confidence interval (CI), 1.01-1.10]. The relative risks were 1.05 (95% CI, 1.02-1.08), 1.06 (95% CI, 1.01-1.11), and 1.08 (95% CI, 0.97-1.20) for light (≤1 drink/day), moderate (>1 to <4 drinks/day), and heavy alcohol drinking (≥4 drinks/day), respectively. This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and prostate cancer, even at high doses.

Rota, M., Scotti, L., Turati, F., Tramacere, I., Islami, F., Bellocco, R., et al. (2012). Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. EUROPEAN JOURNAL OF CANCER PREVENTION, 21(4), 350-359 [10.1097/CEJ.0b013e32834dbc11].

Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation

ROTA, MATTEO
;
SCOTTI, LORENZA
Secondo
;
BELLOCCO, RINO;CORRAO, GIOVANNI;BAGNARDI, VINCENZO
Ultimo
2012

Abstract

Inconsistent results on the relationship between alcohol drinking and prostate cancer have been found. In order to provide a definite quantification of the dose-risk relation, we investigated the risk of prostate cancer at different levels of alcohol consumption, by conducting a meta-analysis of epidemiological studies. We performed a literature search using PubMed of all case-control and cohort studies published as original articles in English up to December 2010. We identified 50 case-control and 22 cohort studies, including a total of 52 899 prostate cancer cases. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates. We performed a dose-risk analysis using nonlinear random-effects meta-regression models. The overall relative risk for any alcohol drinking compared with non/occasional drinking was 1.06 [95% confidence interval (CI), 1.01-1.10]. The relative risks were 1.05 (95% CI, 1.02-1.08), 1.06 (95% CI, 1.01-1.11), and 1.08 (95% CI, 0.97-1.20) for light (≤1 drink/day), moderate (>1 to <4 drinks/day), and heavy alcohol drinking (≥4 drinks/day), respectively. This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and prostate cancer, even at high doses.
Articolo in rivista - Articolo scientifico
alcohol drinking; dose–risk relation; meta-analysis; prostate neoplasms
English
2012
21
4
350
359
none
Rota, M., Scotti, L., Turati, F., Tramacere, I., Islami, F., Bellocco, R., et al. (2012). Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. EUROPEAN JOURNAL OF CANCER PREVENTION, 21(4), 350-359 [10.1097/CEJ.0b013e32834dbc11].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/26113
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