Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality: Objective: To discuss the relationship between XYY chromosome abnormality, psychiatric disorders and epilepsy. Method: Single case report. Results: A 34-year-old man with 47, XYY karyotype and normal intelligence was followed-up at a neuropsychiatric clinic for over 30 years. He was first seen at age 3 years with a history of delayed motor and language development and an immunodeficiency syndrome. At age 8 years he developed refractory local epilepsy, and in late adolescence he started to exhibit increasingly prominent obsessive thoughts. paranoid ideation, and aggressive I sexual fantasies and behaviour. Conclusions: When interpreted within the context of previous literature reports. this case suggests a pathophysiological link between XYY chromosome abnormality, characteristic psychiatric symptoms and epilepsy disorder
Verri, A., Galimberti, C., Perucca, P., Cremante, A., Vernice, M., Uggetti, A. (2008). Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality. GENETIC COUNSELING, 19(4), 373-379.
Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality
VERNICE, MIRTA;
2008
Abstract
Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality: Objective: To discuss the relationship between XYY chromosome abnormality, psychiatric disorders and epilepsy. Method: Single case report. Results: A 34-year-old man with 47, XYY karyotype and normal intelligence was followed-up at a neuropsychiatric clinic for over 30 years. He was first seen at age 3 years with a history of delayed motor and language development and an immunodeficiency syndrome. At age 8 years he developed refractory local epilepsy, and in late adolescence he started to exhibit increasingly prominent obsessive thoughts. paranoid ideation, and aggressive I sexual fantasies and behaviour. Conclusions: When interpreted within the context of previous literature reports. this case suggests a pathophysiological link between XYY chromosome abnormality, characteristic psychiatric symptoms and epilepsy disorder
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