We studied the effects of a four week administration of low doses of ethanol on glycoconjugates of the synaptosomal and microsomal fraction prepared from the brain of rats aged 2 and 7 months. Synaptosomes were the more sensitive to ethanol treatment. Total lipid bound sialic acid and neutral glycolipid and glycoprotein content were significantly reduced only in the synaptosomal fraction, with greater differences in the younger age, while glycoprotein sialic acid was not affected. None of the above differences were statistically significant in the microsomal fraction. Ganglioside pattern was altered only in the 2 month rats, showing a reduction of GM1 and GM1a in the synaptosomal fraction and of GD1a in the microsomal fraction. UDP-Gal: asialo-mucin galactosyltransferase, UDP-Gal: GlcCer galactosyltransferase, and UDP-Gal: GM2 galactosyltransferase activities were decreased and could account for the observed modifications in glycoconjugate content and distribution.

Omodeo Salé, F., Palestini, P. (1994). Chronic ethanol effects on glycoconjugates and glycosyltransferases of rat brain. ALCOHOL, 11(4), 301-306 [10.1016/0741-8329(94)90096-5].

Chronic ethanol effects on glycoconjugates and glycosyltransferases of rat brain

PALESTINI, PAOLA NOVERINA ADA
1994

Abstract

We studied the effects of a four week administration of low doses of ethanol on glycoconjugates of the synaptosomal and microsomal fraction prepared from the brain of rats aged 2 and 7 months. Synaptosomes were the more sensitive to ethanol treatment. Total lipid bound sialic acid and neutral glycolipid and glycoprotein content were significantly reduced only in the synaptosomal fraction, with greater differences in the younger age, while glycoprotein sialic acid was not affected. None of the above differences were statistically significant in the microsomal fraction. Ganglioside pattern was altered only in the 2 month rats, showing a reduction of GM1 and GM1a in the synaptosomal fraction and of GD1a in the microsomal fraction. UDP-Gal: asialo-mucin galactosyltransferase, UDP-Gal: GlcCer galactosyltransferase, and UDP-Gal: GM2 galactosyltransferase activities were decreased and could account for the observed modifications in glycoconjugate content and distribution.
Articolo in rivista - Articolo scientifico
Male; Synaptosomes; Sialic Acids; Glycolipids; Rats, Wistar; Glycosyltransferases; Rats; Animals; Ethanol; Gangliosides; N-Acetylneuraminic Acid; Glycoproteins; Brain; Microsomes; Glycoconjugates
English
ago-1994
11
4
301
306
none
Omodeo Salé, F., Palestini, P. (1994). Chronic ethanol effects on glycoconjugates and glycosyltransferases of rat brain. ALCOHOL, 11(4), 301-306 [10.1016/0741-8329(94)90096-5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/21440
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