Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB resection has allowed to show that MRX facilitates DNA end processing by Exo1 through local unwinding of double-stranded DNA ends

Gobbini, E., Vertemara, J., Longhese, M. (2018). Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity. MOLECULAR & CELLULAR ONCOLOGY, 5(5) [10.1080/23723556.2018.1511208].

Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity

Gobbini, Elisa
Primo
;
Vertemara, Jacopo
Secondo
;
Longhese, Maria Pia
Ultimo
2018

Abstract

Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB resection has allowed to show that MRX facilitates DNA end processing by Exo1 through local unwinding of double-stranded DNA ends
Articolo in rivista - Review Essay
double-strand break; Exo1; MRX; resection; S. cerevisiae; Cancer Research; Molecular Medicine
English
24-ago-2018
2018
5
5
e1511208
open
Gobbini, E., Vertemara, J., Longhese, M. (2018). Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity. MOLECULAR & CELLULAR ONCOLOGY, 5(5) [10.1080/23723556.2018.1511208].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/213198
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