Objective: To evaluate, from a gynecology perspective, the transition from cytology-based HPV screening to primary HPV screening. Methods: Studies examining switching from cytology-based screening to primary HPV-DNA testing with triaging of patients with positive test results were retrieved and reviewed, with a particular focus on screening in an Italian setting. Results: The increased complexity of patient-management decisions when implementing HPV-based screening was a critical issue discussed in the literature. The change in strategy represents a paradigm shift in moving from a medical perspective of identifying the disease in individual patients, to a public-healthcare perspective of excluding HPV from the healthy population and identifying a small sub-group of individuals at increased risk of HPV. Conclusion: With knowledge about HPV screening evolving rapidly, new programs and related algorithms need to be sufficiently flexible to be adjusted according to ongoing research and the validation of new assays. The establishment of a national working group (including epidemiologists, gynecologists, pathologists, and healthcare providers) will be necessary to properly implement and govern this important technical and cultural transition.

Mariani, L., Igidbashian, S., Sandri, M., Vici, P., Landoni, F. (2017). The clinical implementation of primary HPV screening. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 136(3), 266-271 [10.1002/ijgo.12065].

The clinical implementation of primary HPV screening

Landoni, Fabio
2017

Abstract

Objective: To evaluate, from a gynecology perspective, the transition from cytology-based HPV screening to primary HPV screening. Methods: Studies examining switching from cytology-based screening to primary HPV-DNA testing with triaging of patients with positive test results were retrieved and reviewed, with a particular focus on screening in an Italian setting. Results: The increased complexity of patient-management decisions when implementing HPV-based screening was a critical issue discussed in the literature. The change in strategy represents a paradigm shift in moving from a medical perspective of identifying the disease in individual patients, to a public-healthcare perspective of excluding HPV from the healthy population and identifying a small sub-group of individuals at increased risk of HPV. Conclusion: With knowledge about HPV screening evolving rapidly, new programs and related algorithms need to be sufficiently flexible to be adjusted according to ongoing research and the validation of new assays. The establishment of a national working group (including epidemiologists, gynecologists, pathologists, and healthcare providers) will be necessary to properly implement and govern this important technical and cultural transition.
Articolo in rivista - Review Essay
Cervical cancer screening; HPV test; Primary HPV screening; Colposcopy; Cost-Benefit Analysis; Early Detection of Cancer; Female; Human Papillomavirus DNA Tests; Humans; Mass Screening; Papillomaviridae; Papillomavirus Infections; Uterine Cervical Neoplasms; Vaginal Smears; Obstetrics and Gynecology
English
2017
136
3
266
271
none
Mariani, L., Igidbashian, S., Sandri, M., Vici, P., Landoni, F. (2017). The clinical implementation of primary HPV screening. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 136(3), 266-271 [10.1002/ijgo.12065].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/212858
Citazioni
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 4
Social impact