Type 1 diabetes is a chronic disease leading to complications such as peripheral neuropathies, nephropathy and cardiovascular disease. Pancreatic islet transplantation is being extensively investigated for blood glucose control in animals and in human type 1 diabetic patients, but the question of whether it can reverse long-term diabetic complications has not been fully explored. We investigated the effects of islet transplantation on diabetic complications in a rat model of streptozotocin-induced diabetes
Remuzzi, A., Cornolti, R., Bianchi, R., Figliuzzi, M., Porretta Serapiglia, C., Oggioni, N., et al. (2009). Regression of diabetic complications by islet transplantation in the rat. DIABETOLOGIA, 52(12), 2653-2661 [10.1007/s00125-009-1537-y].
Regression of diabetic complications by islet transplantation in the rat
OGGIONI, NORBERTO;CAROZZI, VALENTINA ALDA;AVEZZA, FEDERICA;CAVALETTI, GUIDO ANGELO
2009
Abstract
Type 1 diabetes is a chronic disease leading to complications such as peripheral neuropathies, nephropathy and cardiovascular disease. Pancreatic islet transplantation is being extensively investigated for blood glucose control in animals and in human type 1 diabetic patients, but the question of whether it can reverse long-term diabetic complications has not been fully explored. We investigated the effects of islet transplantation on diabetic complications in a rat model of streptozotocin-induced diabetes
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