Purpose: To evaluate the bactericidal activity of a diluted povidone-iodine formulation (0.6%) in comparison with the most used 5% povidone-iodine solution ophthalmic preparation. Methods: In vitro bactericidal activity comparison between 0.6% povidone-iodine versus 5% povidone-iodine formulations, against these bacteria: Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300, Staphylococcus epidermidis ATCC 12228, linezolid-resistant Staphylococcus epidermidis α99 strain, a clinical isolate, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922. Results: About 0.6% povidone-iodine formulation was demonstrated to be faster than 5% povidone-iodine preparation in killing Gram-positive as well as Gram-negative bacteria. Against a linezolid-resistant methicillin-resistant Staphylococcus epidermidis strain, 0.6% povidone-iodine formulation showed the best antiseptic efficacy requirement of 3-log10 reduction in bacterial load, if compared with the 5% povidone-iodine formulation. Conclusion: Our investigation has demonstrated that the more diluted 0.6% preparation was more rapidly bactericidal than the 5% povidone-iodine formulation, most probably due to the fact that dilution from 5% to 0.6% increases the amount of free iodine. While our finding must be confirmed by in vivo clinical studies, this fact constitutes an intriguing news for what concerns the use of povidone-iodine eye drops in the ocular surface treatment before intravitreal injections as well as ophthalmic surgery.

Musumeci, R., Bandello, F., Martinelli, M., Calaresu, E., Cocuzza, C. (2019). In vitro bactericidal activity of 0.6% povidone-iodine eye drops formulation. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 29(6), 673-677 [10.1177/1120672118802541].

In vitro bactericidal activity of 0.6% povidone-iodine eye drops formulation

Musumeci, R
Primo
;
Martinelli, M;Cocuzza, CE
Ultimo
2019

Abstract

Purpose: To evaluate the bactericidal activity of a diluted povidone-iodine formulation (0.6%) in comparison with the most used 5% povidone-iodine solution ophthalmic preparation. Methods: In vitro bactericidal activity comparison between 0.6% povidone-iodine versus 5% povidone-iodine formulations, against these bacteria: Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300, Staphylococcus epidermidis ATCC 12228, linezolid-resistant Staphylococcus epidermidis α99 strain, a clinical isolate, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922. Results: About 0.6% povidone-iodine formulation was demonstrated to be faster than 5% povidone-iodine preparation in killing Gram-positive as well as Gram-negative bacteria. Against a linezolid-resistant methicillin-resistant Staphylococcus epidermidis strain, 0.6% povidone-iodine formulation showed the best antiseptic efficacy requirement of 3-log10 reduction in bacterial load, if compared with the 5% povidone-iodine formulation. Conclusion: Our investigation has demonstrated that the more diluted 0.6% preparation was more rapidly bactericidal than the 5% povidone-iodine formulation, most probably due to the fact that dilution from 5% to 0.6% increases the amount of free iodine. While our finding must be confirmed by in vivo clinical studies, this fact constitutes an intriguing news for what concerns the use of povidone-iodine eye drops in the ocular surface treatment before intravitreal injections as well as ophthalmic surgery.
Articolo in rivista - Articolo scientifico
bactericidal; intravitreal injection; Povidone-iodine 0.6%;
English
7-ott-2018
2019
29
6
673
677
reserved
Musumeci, R., Bandello, F., Martinelli, M., Calaresu, E., Cocuzza, C. (2019). In vitro bactericidal activity of 0.6% povidone-iodine eye drops formulation. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 29(6), 673-677 [10.1177/1120672118802541].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/207854
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