We present our application of cellulose nanocrystals (CNCs) in the biomedical field. With the aim of identifying novel nanoparticles for drug targeting, we fluorescently labelled the CNCs and carried out a biodistribution study in vivo. Results evidence that CNCs have a peculiar and transient tropism to the limb bones that is likely related to the interaction with the Ca2+ deposits in the bone matrix. We also analyzed and demonstrated the ability of CNCs to inhibit bacterial adhesion to host tissue. All these findings, taken together, make these nanoparticles very promising candidate for a potential development of nano-devices toward bone diseases, as well as new antibacterial agents.

La Ferla, B., Zoia, L., Bigini, P., Di Gennaro, P. (2018). Cellulose nanocrystals as promising nano-devices in the biomedical field. In AIP Conference Proceedings. American Institute of Physics Inc. [10.1063/1.5047773].

Cellulose nanocrystals as promising nano-devices in the biomedical field

La Ferla, B
;
Zoia, L
Membro del Collaboration Group
;
Di Gennaro, P
Membro del Collaboration Group
2018

Abstract

We present our application of cellulose nanocrystals (CNCs) in the biomedical field. With the aim of identifying novel nanoparticles for drug targeting, we fluorescently labelled the CNCs and carried out a biodistribution study in vivo. Results evidence that CNCs have a peculiar and transient tropism to the limb bones that is likely related to the interaction with the Ca2+ deposits in the bone matrix. We also analyzed and demonstrated the ability of CNCs to inhibit bacterial adhesion to host tissue. All these findings, taken together, make these nanoparticles very promising candidate for a potential development of nano-devices toward bone diseases, as well as new antibacterial agents.
paper
CNCs, bone targeting, antibacterial
English
2nd NanoInnovation 2017 Conference and Exhibition
2017
AIP Conference Proceedings
9780735417069
2018
1990
020019
http://scitation.aip.org/content/aip/proceeding/aipcp
open
La Ferla, B., Zoia, L., Bigini, P., Di Gennaro, P. (2018). Cellulose nanocrystals as promising nano-devices in the biomedical field. In AIP Conference Proceedings. American Institute of Physics Inc. [10.1063/1.5047773].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/204100
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