Various types of nanoparticles (NPs), such as Liposomes, Solid Lipid NPs and Polymeric NPs, are being extensively explored for their potentialities in the medical field. NPs are attractive tools in biomedical applications thanks to their biocompatibility, non-immunogenicity, non-toxicity, biodegradability, high physical stability, possibility of drug loading and releasing, and higher probability for surface functionalization. The project is devoted to the synthesis of NPs functionalized with amyloid-beta ligands (Aβ-ligands), imaging tools and/or blood brain barrier-transporters (BBB-transporters) for the cure and the diagnosis of Alzheimer’s disease (AD). Amyloid β (Aβ) aggregates are considered as possible targets for therapy and/or diagnosis of Alzheimer disease (AD). It has been previously shown that some small molecules targets Aβ plaques and, among them, curcumin interacts with their precursors, suggesting a potential role for the prevention or the treatment of AD. Herein, a chemoselective ligation procedure was used to generate NPs decorated with a curcumin derivative, designed to maintain all the features required for interaction with Aβ. In summary, this thesis describes the preparation and characterization of new curcumin derivatives and NPs, with affinity for Aβ peptide. They could be exploited as ligands and/or vectors for the targeted delivery of new diagnostic and therapeutic molecules for AD. The NPs preparations and the biological results were obtained in collaboration with scientists involved in a joint European project: NAD - Nanoparticles for therapy and diagnosis of Alzheimer’s Disease - 2008-2012, FP7-NMP-2007-LARGE-1-Large-scale integrating project NMP-2007-4.0-4 Substantial innovation in the European medical industry: development of nanotechnology-based systems for in-vivo diagnosis and therapy.

(2011). Design and systhesis of nanoparticles for therapy and imaging of Alzheimer's disease. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2011).

Design and systhesis of nanoparticles for therapy and imaging of Alzheimer's disease

ZONA, CRISTIANO
2011

Abstract

Various types of nanoparticles (NPs), such as Liposomes, Solid Lipid NPs and Polymeric NPs, are being extensively explored for their potentialities in the medical field. NPs are attractive tools in biomedical applications thanks to their biocompatibility, non-immunogenicity, non-toxicity, biodegradability, high physical stability, possibility of drug loading and releasing, and higher probability for surface functionalization. The project is devoted to the synthesis of NPs functionalized with amyloid-beta ligands (Aβ-ligands), imaging tools and/or blood brain barrier-transporters (BBB-transporters) for the cure and the diagnosis of Alzheimer’s disease (AD). Amyloid β (Aβ) aggregates are considered as possible targets for therapy and/or diagnosis of Alzheimer disease (AD). It has been previously shown that some small molecules targets Aβ plaques and, among them, curcumin interacts with their precursors, suggesting a potential role for the prevention or the treatment of AD. Herein, a chemoselective ligation procedure was used to generate NPs decorated with a curcumin derivative, designed to maintain all the features required for interaction with Aβ. In summary, this thesis describes the preparation and characterization of new curcumin derivatives and NPs, with affinity for Aβ peptide. They could be exploited as ligands and/or vectors for the targeted delivery of new diagnostic and therapeutic molecules for AD. The NPs preparations and the biological results were obtained in collaboration with scientists involved in a joint European project: NAD - Nanoparticles for therapy and diagnosis of Alzheimer’s Disease - 2008-2012, FP7-NMP-2007-LARGE-1-Large-scale integrating project NMP-2007-4.0-4 Substantial innovation in the European medical industry: development of nanotechnology-based systems for in-vivo diagnosis and therapy.
NICOTRA, FRANCESCO
Nanoparticles (NPs), Amyloid-beta peptide (A-beta), Alzheimer’s disease (AD), Small Molecules, Curcumin, Click Chemistry, Stability, Affinity
CHIM/06 - CHIMICA ORGANICA
English
10-feb-2011
Scuola di dottorato di Scienze
SCIENZE CHIMICHE - 18R
23
2009/2010
open
(2011). Design and systhesis of nanoparticles for therapy and imaging of Alzheimer's disease. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2011).
File in questo prodotto:
File Dimensione Formato  
phd_unimib_716391.pdf

Accesso Aperto

Tipologia di allegato: Doctoral thesis
Dimensione 4.6 MB
Formato Adobe PDF
4.6 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/19222
Citazioni
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
Social impact