Objective: This study aimed to investigate the relationship between polyunsaturated fatty acids (PUFAs) status, cognitive, and behavioral traits of ADHD in school-aged children. Method: Seventy-three children with and without ADHD were assessed with cognitive tasks and behavioral rating scales including quality of life and global functioning at baseline of an intervention trial (clinicaltrials.gov NCT01796262). Correlation analyses were performed between the cognitive tasks/behavioral ratings and blood PUFA levels. Results: Children with ADHD had lower levels of DHA, omega-3 index, and total PUFA. PUFAs were positively associated with behavior but not consistently related to cognitive domains. Conclusion: The present study confirms that children with ADHD display abnormal fatty acid profiles within an Italian setting. Furthermore, PUFAs were associated with behavior but not with cognition. Accordingly, for the first time, lower blood levels of PUFA were associated not only with symptoms of ADHD but also with a poorer quality of life.

Crippa, A., Agostoni, C., Mauri, M., Molteni, M., Nobile, M. (2018). Polyunsaturated fatty acids are associated with behavior but not with cognition in children with and without Attention Deficit Hyperactivity Disorder (ADHD): an Italian study. JOURNAL OF ATTENTION DISORDERS, 22(10), 971-983 [10.1177/1087054716629215].

Polyunsaturated fatty acids are associated with behavior but not with cognition in children with and without Attention Deficit Hyperactivity Disorder (ADHD): an Italian study

Crippa, A
Primo
;
MAURI, MADDALENA;
2018

Abstract

Objective: This study aimed to investigate the relationship between polyunsaturated fatty acids (PUFAs) status, cognitive, and behavioral traits of ADHD in school-aged children. Method: Seventy-three children with and without ADHD were assessed with cognitive tasks and behavioral rating scales including quality of life and global functioning at baseline of an intervention trial (clinicaltrials.gov NCT01796262). Correlation analyses were performed between the cognitive tasks/behavioral ratings and blood PUFA levels. Results: Children with ADHD had lower levels of DHA, omega-3 index, and total PUFA. PUFAs were positively associated with behavior but not consistently related to cognitive domains. Conclusion: The present study confirms that children with ADHD display abnormal fatty acid profiles within an Italian setting. Furthermore, PUFAs were associated with behavior but not with cognition. Accordingly, for the first time, lower blood levels of PUFA were associated not only with symptoms of ADHD but also with a poorer quality of life.
Articolo in rivista - Articolo scientifico
ADHD, fatty acids, cognition, behavior, quality of life
English
2018
22
10
971
983
none
Crippa, A., Agostoni, C., Mauri, M., Molteni, M., Nobile, M. (2018). Polyunsaturated fatty acids are associated with behavior but not with cognition in children with and without Attention Deficit Hyperactivity Disorder (ADHD): an Italian study. JOURNAL OF ATTENTION DISORDERS, 22(10), 971-983 [10.1177/1087054716629215].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/190344
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