Objectives: It remains unclear to what extent postoperative delirium (POD) affects the incidence of dementia in hip fracture patients, and the methods used to detect delirium and dementia require validation. The aim of this study was to investigate the development of dementia within 3 years of femoral neck fracture repair surgery, with a focus on POD as a potential predictive factor. Methods: Patients were assessed for cognition, delirium, depression, psychological well-being, and nutritional status during their hospitalization as well as 4, 12, and 36 months after the operation. Logistic regression models were used to analyse factors associated with POD and factors associated with the development of dementia. Results: The study sample consisted of 135 patients without a history of dementia, of whom 20 (14.8%) were delirious preoperatively and 75 (55.5%) postoperatively. Three years after their operations, 43/135 patients (31.8%) were diagnosed with dementia. A greater portion of patients diagnosed with dementia (39/43, 90.6%) than patients with no dementia (36/92, 39.1%) were included among the 75 patients who had experienced POD (P < 0.001). In a logistic regression model, after adjustment for covariates (age, sex, diabetes, delirium pre-and postoperatively, hyperactive delirium, days with delirium, urinary tract infection, and Mini Nutritional Assessment score), POD emerged an independent predictor for the development of new dementia (odds ratio, 15.6; 95% confidence interval, 2.6–91.6) within 3 years after the operation. Conclusion: Geriatric hip fracture patients who exhibit POD should be monitored closely for the development of dementia.

Olofsson, B., Persson, M., Bellelli, G., Morandi, A., Gustafson, Y., Stenvall, M. (2018). Development of dementia in patients with femoral neck fracture who experience postoperative delirium—A three-year follow-up study. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 33(4), 623-632 [10.1002/gps.4832].

Development of dementia in patients with femoral neck fracture who experience postoperative delirium—A three-year follow-up study

Bellelli, G.;
2018

Abstract

Objectives: It remains unclear to what extent postoperative delirium (POD) affects the incidence of dementia in hip fracture patients, and the methods used to detect delirium and dementia require validation. The aim of this study was to investigate the development of dementia within 3 years of femoral neck fracture repair surgery, with a focus on POD as a potential predictive factor. Methods: Patients were assessed for cognition, delirium, depression, psychological well-being, and nutritional status during their hospitalization as well as 4, 12, and 36 months after the operation. Logistic regression models were used to analyse factors associated with POD and factors associated with the development of dementia. Results: The study sample consisted of 135 patients without a history of dementia, of whom 20 (14.8%) were delirious preoperatively and 75 (55.5%) postoperatively. Three years after their operations, 43/135 patients (31.8%) were diagnosed with dementia. A greater portion of patients diagnosed with dementia (39/43, 90.6%) than patients with no dementia (36/92, 39.1%) were included among the 75 patients who had experienced POD (P < 0.001). In a logistic regression model, after adjustment for covariates (age, sex, diabetes, delirium pre-and postoperatively, hyperactive delirium, days with delirium, urinary tract infection, and Mini Nutritional Assessment score), POD emerged an independent predictor for the development of new dementia (odds ratio, 15.6; 95% confidence interval, 2.6–91.6) within 3 years after the operation. Conclusion: Geriatric hip fracture patients who exhibit POD should be monitored closely for the development of dementia.
Articolo in rivista - Articolo scientifico
cognitive impairment; femoral neck fracture; geriatrics; logistic regression; mortality;
Cognitive impairment; Femoral neck fracture; Geriatrics; Logistic regression; Mortality; Geriatrics and Gerontology; Psychiatry and Mental Health
English
2018
33
4
623
632
none
Olofsson, B., Persson, M., Bellelli, G., Morandi, A., Gustafson, Y., Stenvall, M. (2018). Development of dementia in patients with femoral neck fracture who experience postoperative delirium—A three-year follow-up study. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 33(4), 623-632 [10.1002/gps.4832].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/184159
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