Background and aims Meta-analyses of randomized control trials investigating the association between incident diabetes and statin use showed an increased risk of new-onset diabetes (NOD) from 9% to 13% associated with statins. However, short follow-up period, unpowered sample size, and lack of pre-specified diagnostic criteria for diabetes detection could be responsible of an underestimation of this risk. We conducted a meta-analysis of published observational studies to evaluate the association between statins use and risk of NOD. Methods and results PubMed, EMBASE and MEDLINE databases were searched from inception to June 30, 2016 for cohort and case–control studies with risk of NOD in users vs nonusers, on ≥1000 subjects followed-up for ≥1 year. Two review authors assessed study eligibility and risk of bias and undertook data extraction independently. Pooled estimates were calculated by a random-effects model and between-study heterogeneity was tested and measured by I2index. Furthermore, stratified analyses and the evaluation of publication bias were performed. Finally, the meta-analysis included 20 studies, 18 cohort and 2 case–control studies. Overall, NOD risk was higher in statin users than nonusers (RR 1.44; 95% CI 1.31–1.58). High between-study heterogeneity (I2 = 97%) was found. Estimates for all single statins showed a class effect, from rosuvastatin (RR 1.61; 1.30–1.98) to simvastatin (RR 1.38; 1.19–1.61). Conclusions The present meta-analysis confirms and reinforces the evidence of a diabetogenic effect by statins utilization. These observations confirm the need of a rigorous monitoring of patients taking statins, in particular pre-diabetic patients or patients presenting with established risk factors for diabetes

Casula, M., Mozzanica, F., Scotti, L., Tragni, E., Pirillo, A., Corrao, G., et al. (2017). Statin use and risk of new-onset diabetes: A meta-analysis of observational studies. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 27(5), 396-406 [10.1016/j.numecd.2017.03.001].

Statin use and risk of new-onset diabetes: A meta-analysis of observational studies

Scotti, L.
Membro del Collaboration Group
;
Corrao, G.
Penultimo
Membro del Collaboration Group
;
2017

Abstract

Background and aims Meta-analyses of randomized control trials investigating the association between incident diabetes and statin use showed an increased risk of new-onset diabetes (NOD) from 9% to 13% associated with statins. However, short follow-up period, unpowered sample size, and lack of pre-specified diagnostic criteria for diabetes detection could be responsible of an underestimation of this risk. We conducted a meta-analysis of published observational studies to evaluate the association between statins use and risk of NOD. Methods and results PubMed, EMBASE and MEDLINE databases were searched from inception to June 30, 2016 for cohort and case–control studies with risk of NOD in users vs nonusers, on ≥1000 subjects followed-up for ≥1 year. Two review authors assessed study eligibility and risk of bias and undertook data extraction independently. Pooled estimates were calculated by a random-effects model and between-study heterogeneity was tested and measured by I2index. Furthermore, stratified analyses and the evaluation of publication bias were performed. Finally, the meta-analysis included 20 studies, 18 cohort and 2 case–control studies. Overall, NOD risk was higher in statin users than nonusers (RR 1.44; 95% CI 1.31–1.58). High between-study heterogeneity (I2 = 97%) was found. Estimates for all single statins showed a class effect, from rosuvastatin (RR 1.61; 1.30–1.98) to simvastatin (RR 1.38; 1.19–1.61). Conclusions The present meta-analysis confirms and reinforces the evidence of a diabetogenic effect by statins utilization. These observations confirm the need of a rigorous monitoring of patients taking statins, in particular pre-diabetic patients or patients presenting with established risk factors for diabetes
Articolo in rivista - Articolo scientifico
Incident diabetes; Meta-analysis; Observational studies; Statins; Biomarkers; Blood Glucose; Diabetes Mellitus; Dyslipidemias; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Observational Studies as Topic; Odds Ratio; Risk Assessment; Risk Factors; Medicine (miscellaneous); Endocrinology, Diabetes and Metabolism; Nutrition and Dietetics; Cardiology and Cardiovascular Medicine
English
2017
27
5
396
406
reserved
Casula, M., Mozzanica, F., Scotti, L., Tragni, E., Pirillo, A., Corrao, G., et al. (2017). Statin use and risk of new-onset diabetes: A meta-analysis of observational studies. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 27(5), 396-406 [10.1016/j.numecd.2017.03.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/180271
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