Carbon-11 labeled acetone is a useful radiosynthetic precursor. Previously, strict control of no-carrier-added stoichiometry was required to prepare it from reaction of CO2 and methyl lithium. However, excess methyl lithium may be selectively quenched to avoid reaction with nascent acetone to give tert-butanol. We report a simple pKa-based strategy to sequentially and selectively quench MeLi and acetone to give yields of up to 100% acetone even in the presence of a large excess of MeLi. The method gives good yields of acetone under conditions that previously precluded its synthesis

Studenov, A., Berridge, M., Soloviev, D., Matarrese, M., Todde, S. (1999). High yield synthesis of [11C]-acetone through selective quenching of methyl lithium. NUCLEAR MEDICINE AND BIOLOGY, 26(4), 431-435 [10.1016/S0969-8051(99)00003-7].

High yield synthesis of [11C]-acetone through selective quenching of methyl lithium

TODDE, SERGIO CAMILLO
1999

Abstract

Carbon-11 labeled acetone is a useful radiosynthetic precursor. Previously, strict control of no-carrier-added stoichiometry was required to prepare it from reaction of CO2 and methyl lithium. However, excess methyl lithium may be selectively quenched to avoid reaction with nascent acetone to give tert-butanol. We report a simple pKa-based strategy to sequentially and selectively quench MeLi and acetone to give yields of up to 100% acetone even in the presence of a large excess of MeLi. The method gives good yields of acetone under conditions that previously precluded its synthesis
Articolo in rivista - Articolo scientifico
Methyllithium; Acetone; Carbon-11
English
1999
26
4
431
435
none
Studenov, A., Berridge, M., Soloviev, D., Matarrese, M., Todde, S. (1999). High yield synthesis of [11C]-acetone through selective quenching of methyl lithium. NUCLEAR MEDICINE AND BIOLOGY, 26(4), 431-435 [10.1016/S0969-8051(99)00003-7].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/17402
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