Aggressive reduction of blood pressure may increase cardiovascular events (the J-curve phenomenon) in certain populations. In this regard, most studies in patients with chronic kidney disease have shown a J curve for cardiovascular morbidity and mortality, and this phenomenon persists after adjusting for confounding factors. Since there is no evidence that a straighter blood pressure target (<130/70 mm Hg) could improve renal outcomes, the increased cardiovascular risk associated with extreme blood pressure reduction should be seen as undesirable. Moreover, the intensive control of blood pressure may induce an unintended reduction of renal function and this decrease, in turn, may increase cardiovascular risk.

Robles, N., Hernandez Gallego, R., Fici, F., Grassi, G. (2017). Does a blood pressure J curve exist for patients with chronic kidney disease?. THE JOURNAL OF CLINICAL HYPERTENSION, 19(8), 764-770 [10.1111/jch.13024].

Does a blood pressure J curve exist for patients with chronic kidney disease?

GRASSI, GUIDO
Ultimo
2017

Abstract

Aggressive reduction of blood pressure may increase cardiovascular events (the J-curve phenomenon) in certain populations. In this regard, most studies in patients with chronic kidney disease have shown a J curve for cardiovascular morbidity and mortality, and this phenomenon persists after adjusting for confounding factors. Since there is no evidence that a straighter blood pressure target (<130/70 mm Hg) could improve renal outcomes, the increased cardiovascular risk associated with extreme blood pressure reduction should be seen as undesirable. Moreover, the intensive control of blood pressure may induce an unintended reduction of renal function and this decrease, in turn, may increase cardiovascular risk.
Articolo in rivista - Review Essay
J curve; chronic kidney disease; hypertension
English
2017
19
8
764
770
none
Robles, N., Hernandez Gallego, R., Fici, F., Grassi, G. (2017). Does a blood pressure J curve exist for patients with chronic kidney disease?. THE JOURNAL OF CLINICAL HYPERTENSION, 19(8), 764-770 [10.1111/jch.13024].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/171443
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