Estimation of self-similarity is a promising tool for quantifying alterations in cardiovascular dynamics. To evaluate the as yet unexplored influence of sympathetic vascular regulation on the scaling exponent, namely on the parameter characterizing self-similarity, we studied patients with a spinal cord injury as a model of progressively impaired vascular control. We considered 24 able-bodied subjects (AB) and 23 paraplegics with increasing lesion levels: between T12 and L4 (n=7); T5 and T11 (n=9); and C6 and T4 (n=7). We recorded the heart rate in three conditions characterized by increasing sympathetic activation: supine (SUP), sitting (SIT) and exercise (EXE). We calculated the scaling exponent by detrended fluctuation analysis (HDFA). Sympathetic activation had different effects on HDFA, depending on the lesion level. H DFA tended to decrease in AB from SUP (0.85+0.02; mean+SEM) and SIT (0.84+0.02) to EXE (0.79+0.02). It remained constant in the T 12-L4 group (0.92+0.04, 0.94+0.05 and 0.94+0.04, respectively), while it increased significantly in the T5-T 11 group (0.88+0.07, 0.94+0.05, 1.00+0.08) and increased even more in the C6-T4 group (0.83+0.07, 0.91+0.05, 1.06+0.06). Results suggest that heart-rate self-similarity depends on vascular sympathetic control, because it is altered by spinal-cord lesions, even when cardiac neural control is intact. ©2006 by Walter de Gruyter.

Castiglioni, P., Merati, G., Veicsteinas, A., Parati, G., DI RIENZO, M. (2006). Influence of sympathetic vascular regulation on heart-rate scaling structure: Spinal cord lesion as a model of progressively impaired autonomic control. BIOMEDIZINISCHE TECHNIK, 51(4), 240-243 [10.1515/BMT.2006.046].

Influence of sympathetic vascular regulation on heart-rate scaling structure: Spinal cord lesion as a model of progressively impaired autonomic control

PARATI, GIANFRANCO
Penultimo
;
DI RIENZO, MARCO
Ultimo
2006

Abstract

Estimation of self-similarity is a promising tool for quantifying alterations in cardiovascular dynamics. To evaluate the as yet unexplored influence of sympathetic vascular regulation on the scaling exponent, namely on the parameter characterizing self-similarity, we studied patients with a spinal cord injury as a model of progressively impaired vascular control. We considered 24 able-bodied subjects (AB) and 23 paraplegics with increasing lesion levels: between T12 and L4 (n=7); T5 and T11 (n=9); and C6 and T4 (n=7). We recorded the heart rate in three conditions characterized by increasing sympathetic activation: supine (SUP), sitting (SIT) and exercise (EXE). We calculated the scaling exponent by detrended fluctuation analysis (HDFA). Sympathetic activation had different effects on HDFA, depending on the lesion level. H DFA tended to decrease in AB from SUP (0.85+0.02; mean+SEM) and SIT (0.84+0.02) to EXE (0.79+0.02). It remained constant in the T 12-L4 group (0.92+0.04, 0.94+0.05 and 0.94+0.04, respectively), while it increased significantly in the T5-T 11 group (0.88+0.07, 0.94+0.05, 1.00+0.08) and increased even more in the C6-T4 group (0.83+0.07, 0.91+0.05, 1.06+0.06). Results suggest that heart-rate self-similarity depends on vascular sympathetic control, because it is altered by spinal-cord lesions, even when cardiac neural control is intact. ©2006 by Walter de Gruyter.
Articolo in rivista - Articolo scientifico
DFA; Scaling exponent; Spinal lesion; Sympathetic tone; Autonomic Nervous System; Autonomic Nervous System Diseases; Computer Simulation; Feedback; Heart; Humans; Models, Cardiovascular; Models, Neurological; Spinal Cord Injuries; Heart Rate; Vasomotor System; Biomedical Engineering; Health Informatics
English
2006
51
4
240
243
none
Castiglioni, P., Merati, G., Veicsteinas, A., Parati, G., DI RIENZO, M. (2006). Influence of sympathetic vascular regulation on heart-rate scaling structure: Spinal cord lesion as a model of progressively impaired autonomic control. BIOMEDIZINISCHE TECHNIK, 51(4), 240-243 [10.1515/BMT.2006.046].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/171046
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