Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. Copyright (C) 2000 Elsevier Science Ltd.

LA FERLA, B., Lay, L., Russo, G., Panza, L. (2000). Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides. TETRAHEDRON-ASYMMETRY, 11(18), 3647-3651 [10.1016/S0957-4166(00)00342-6].

Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides

LA FERLA, BARBARA;
2000

Abstract

Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. Copyright (C) 2000 Elsevier Science Ltd.
Articolo in rivista - Articolo scientifico
regioselectivity, carbohydrate
English
2000
11
18
3647
3651
none
LA FERLA, B., Lay, L., Russo, G., Panza, L. (2000). Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides. TETRAHEDRON-ASYMMETRY, 11(18), 3647-3651 [10.1016/S0957-4166(00)00342-6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/17012
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