We evaluated [11C]fluvoxamine as a tracer for the serotonin re-uptake site. Studies of the distribution of the tracer in rat and primate brain showed adequate uptake of [11C]fluvoxamine, but failed to reveal regions with known high density of serotoninergic re-uptake sites. Pretreatment with unlabeled fluvoxamine did not substantially change the distribution. In rat brain tissue, nearly all radioactivity represented intact [11C]fluvoxamine. [11C]Fluvoxamine does not function as a tracer for serotonin re-uptake sites, owing to high nonspecific binding in the brain.
Wollmer, P., Moresco, R., Simonelli, P., Matarrese, M., Rigamonti, M., Ortu, G., et al. (2000). Evaluation of [O-methyl-(11)C]fluvoxamine as a tracer for serotonin re-uptake sites. NUCLEAR MEDICINE AND BIOLOGY, 27(2), 177-181 [10.1016/S0969-8051(99)00106-7].
Evaluation of [O-methyl-(11)C]fluvoxamine as a tracer for serotonin re-uptake sites
MORESCO, ROSA MARIA;SIMONELLI, PASQUALE;KIENLE, MARZIA DONATELLA;FAZIO, FERRUCCIO
2000
Abstract
We evaluated [11C]fluvoxamine as a tracer for the serotonin re-uptake site. Studies of the distribution of the tracer in rat and primate brain showed adequate uptake of [11C]fluvoxamine, but failed to reveal regions with known high density of serotoninergic re-uptake sites. Pretreatment with unlabeled fluvoxamine did not substantially change the distribution. In rat brain tissue, nearly all radioactivity represented intact [11C]fluvoxamine. [11C]Fluvoxamine does not function as a tracer for serotonin re-uptake sites, owing to high nonspecific binding in the brain.
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