A non natural glycosphingolipid containing the mucin derived, cancer associated disaccharide moiety Galβ1→3GalNAc, the T-antigen, α linked to a ceramide, has been synthesised via the protected disaccharide glycosyl trichloroacetimidate. The product has potential as a cancer vaccine.
Cipolla, L., Meldal, M. (2000). Synthesis of a non-natural T-antigen containing glycosphingolipid. CARBOHYDRATE LETTERS, 4(1), 29-34.
Synthesis of a non-natural T-antigen containing glycosphingolipid
CIPOLLA, LAURA FRANCESCA;
2000
Abstract
A non natural glycosphingolipid containing the mucin derived, cancer associated disaccharide moiety Galβ1→3GalNAc, the T-antigen, α linked to a ceramide, has been synthesised via the protected disaccharide glycosyl trichloroacetimidate. The product has potential as a cancer vaccine.
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