The effect of ghrelin, a recently characterized endogenous receptor agonist for growth hormone (GH) secretagogue receptors, on feeding and penile erection was compared with that of EP 80661, a peptide analogue of the GH secretagogue hexarelin, previously identified for its pro-erectile activity when injected into the paraventricular nucleus of the hypothalamus of male rats. Ghrelin (0.01-1 mug), but not EP 80661 (0.02-1 mug), was found to be particularly effective in enhancing feeding. The minimal effective dose of ghrelin was 0.1 mug, which increased food intake by 88%, while the maximal response (355% above control values) was found with 1 mug of the peptide. The enhancing effect of ghrelin on feeding was prevented by the prior administration of the neuropeptide Y Y5 receptor antagonist (DTyr(2), DThr(32)) neuropeptide Y (NPY, 10 mug), but not by the GH-RH receptor antagonist MZ-4-71 (10 mug), or by EP 91073, a hexarelin analogue that antagonizes the pro-erectile effect of EP 80661 (10 mug), given into the lateral ventricles. In contrast, ghrelin failed to induce penile erection at all doses tested, while EP 80661 induced penile erection in a dose-dependent manner. The proerectile effect of EP 80661 was prevented by EP 91073 (10 mug), but not by (DTyr(2), DThr(32)) NPY (10 mug) or by the GH-RH receptor antagonist MZ 4-71 (10 mug), given into the lateral ventricles. The present results provide further support to the hypothesis that the GH secretagogue receptors mediating feeding are different from those mediating penile erection and activated by pro-erectile EP peptides. (C) 2002 Published by Elsevier Science Ireland Ltd

Melis, M., Mascia, M., Succu, S., Torsello, A., Muller, E., Deghenghi, R., et al. (2002). Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection. NEUROSCIENCE LETTERS, 329(3), 339-343 [10.1016/S0304-3940(02)00673-0].

Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection

Torsello, AB;
2002

Abstract

The effect of ghrelin, a recently characterized endogenous receptor agonist for growth hormone (GH) secretagogue receptors, on feeding and penile erection was compared with that of EP 80661, a peptide analogue of the GH secretagogue hexarelin, previously identified for its pro-erectile activity when injected into the paraventricular nucleus of the hypothalamus of male rats. Ghrelin (0.01-1 mug), but not EP 80661 (0.02-1 mug), was found to be particularly effective in enhancing feeding. The minimal effective dose of ghrelin was 0.1 mug, which increased food intake by 88%, while the maximal response (355% above control values) was found with 1 mug of the peptide. The enhancing effect of ghrelin on feeding was prevented by the prior administration of the neuropeptide Y Y5 receptor antagonist (DTyr(2), DThr(32)) neuropeptide Y (NPY, 10 mug), but not by the GH-RH receptor antagonist MZ-4-71 (10 mug), or by EP 91073, a hexarelin analogue that antagonizes the pro-erectile effect of EP 80661 (10 mug), given into the lateral ventricles. In contrast, ghrelin failed to induce penile erection at all doses tested, while EP 80661 induced penile erection in a dose-dependent manner. The proerectile effect of EP 80661 was prevented by EP 91073 (10 mug), but not by (DTyr(2), DThr(32)) NPY (10 mug) or by the GH-RH receptor antagonist MZ 4-71 (10 mug), given into the lateral ventricles. The present results provide further support to the hypothesis that the GH secretagogue receptors mediating feeding are different from those mediating penile erection and activated by pro-erectile EP peptides. (C) 2002 Published by Elsevier Science Ireland Ltd
Articolo in rivista - Articolo scientifico
ghrelin; EP 80661; growth hormone (GH) secretagogue receptors; feeding; penile erection; paraventricular nucleus
English
2002
329
3
339
343
19138
none
Melis, M., Mascia, M., Succu, S., Torsello, A., Muller, E., Deghenghi, R., et al. (2002). Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection. NEUROSCIENCE LETTERS, 329(3), 339-343 [10.1016/S0304-3940(02)00673-0].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/1649
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