Based on the "lipotoxic" hypothesis, the free fatty acid flux from the excessive amount of adipose tissue toward the peripheral tissues would induce the development of insulin resistance especially when the triglyceride storage or the concentration of intermediate fat metabolites (diacylglycerides, ceramides) within the cytoplasm of these cells become excessive. Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver damage, ranging from simple steatosis to steatohepatitis and advanced fibrosis. NAFLD is associated with general and intra-abdominal obesity and with a reduced ability of insulin to stimulate metabolic pathways in the liver itself and in other tissues. There are animal models and models in human diseases sustaining the hypothesis that a primary hepatic disease may determine the development of type 2 diabetes (T2DM). Epidemiologic data generated on surrogate markers of NAFLD (transaminases and γ-glutamyltransferase), semiquantitative assessment of fatty liver (ultrasound), and surrogate algorithms of NAFLD also support a causative effect of NAFLD on the risk to develop T2DM. In spite of the presence of these indirect associations, a clear-cut link between NAFLD and abnormal β-cell function is yet to be reported. Therefore, more data are warranted to prove what is considered a likely causative relationship between NAFLD and T2DM. © 2011 Springer Science+Business Media, LLC

Lattuada, G., Ragogna, F., Perseghin, G. (2011). Why does NAFLD predict type 2 diabetes?. CURRENT DIABETES REPORT, 11(3), 167-172 [10.1007/s11892-011-0190-2].

Why does NAFLD predict type 2 diabetes?

PERSEGHIN, GIANLUCA
Ultimo
2011

Abstract

Based on the "lipotoxic" hypothesis, the free fatty acid flux from the excessive amount of adipose tissue toward the peripheral tissues would induce the development of insulin resistance especially when the triglyceride storage or the concentration of intermediate fat metabolites (diacylglycerides, ceramides) within the cytoplasm of these cells become excessive. Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver damage, ranging from simple steatosis to steatohepatitis and advanced fibrosis. NAFLD is associated with general and intra-abdominal obesity and with a reduced ability of insulin to stimulate metabolic pathways in the liver itself and in other tissues. There are animal models and models in human diseases sustaining the hypothesis that a primary hepatic disease may determine the development of type 2 diabetes (T2DM). Epidemiologic data generated on surrogate markers of NAFLD (transaminases and γ-glutamyltransferase), semiquantitative assessment of fatty liver (ultrasound), and surrogate algorithms of NAFLD also support a causative effect of NAFLD on the risk to develop T2DM. In spite of the presence of these indirect associations, a clear-cut link between NAFLD and abnormal β-cell function is yet to be reported. Therefore, more data are warranted to prove what is considered a likely causative relationship between NAFLD and T2DM. © 2011 Springer Science+Business Media, LLC
Articolo in rivista - Articolo scientifico
Fatty liver; FFA; Magnetic resonance spectroscopy; Nonalcoholic fatty liver disease (NAFLD); Endocrinology, Diabetes and Metabolism; Internal Medicine
English
2011
11
3
167
172
reserved
Lattuada, G., Ragogna, F., Perseghin, G. (2011). Why does NAFLD predict type 2 diabetes?. CURRENT DIABETES REPORT, 11(3), 167-172 [10.1007/s11892-011-0190-2].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/164131
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