Throughout vertebrate evolution, Sox2 marks the developing nervous system from its earliest developmental stages and, therein, the most undifferentiated precursor cells, including stem cells. Recent gene targeting studies investigated the function of Sox2 in two neuronal systems: the developing eye and brain. These studies uncovered a requirement for Sox2 in the maintenance of neural stem cells, as well as a downstream role in the differentiation of specific neuron sub-types. In both systems, Sox2 action is markedly dose-dependent, and downstream-target gene studies are beginning to reveal the mechanisms of Sox2 function.

Pevny, L., Nicolis, S. (2010). Sox2 roles in neural stem cells. THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42(3), 421-424 [10.1016/j.biocel.2009.08.018].

Sox2 roles in neural stem cells

NICOLIS, SILVIA KIRSTEN
2010

Abstract

Throughout vertebrate evolution, Sox2 marks the developing nervous system from its earliest developmental stages and, therein, the most undifferentiated precursor cells, including stem cells. Recent gene targeting studies investigated the function of Sox2 in two neuronal systems: the developing eye and brain. These studies uncovered a requirement for Sox2 in the maintenance of neural stem cells, as well as a downstream role in the differentiation of specific neuron sub-types. In both systems, Sox2 action is markedly dose-dependent, and downstream-target gene studies are beginning to reveal the mechanisms of Sox2 function.
Articolo in rivista - Articolo scientifico
Animal models; Gene regulation; Neural development; Neural stem cells; Sox2;
English
2010
42
3
421
424
none
Pevny, L., Nicolis, S. (2010). Sox2 roles in neural stem cells. THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42(3), 421-424 [10.1016/j.biocel.2009.08.018].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/16192
Citazioni
  • Scopus 275
  • ???jsp.display-item.citation.isi??? 254
Social impact