Recent epidemiological studies have demonstrated that the consumption of healthy foods that are particularly rich in polyphenols might reduce the incidence of cancer and neurodegenerative diseases. In particular, chlorogenic acids (CGAs) occur ubiquitously in food and represent the most abundant polyphenols in the human diet. A number of beneficial biological effects of CGAs, such as anti-inflammatory activity, anti-carcinogenic activity, and protection against neurodegenerative diseases, have been reported. However, the molecular mechanisms at the base of these biological activities have not yet been investigated in depth. By combining NMR spectroscopy, molecular docking, surface plasmon resonance and ex vivo assays of the Ras-dependent breast cancer cell line MDA-MB-231, we contribute to the elucidation of the molecular basis of the activity of CGAs and natural extracts from green and roasted coffee beans as chemoprotective dietary supplements.

Palmioli, A., Ciaramelli, C., Tisi, R., Spinelli, M., De Sanctis, G., Sacco, E., et al. (2017). Natural compounds in cancer prevention: effects of coffee extracts and their main polyphenolic component 5-CQA on oncogenic Ras proteins. CHEMISTRY - AN ASIAN JOURNAL, 12(18), 2457-2466 [10.1002/asia.201700844].

Natural compounds in cancer prevention: effects of coffee extracts and their main polyphenolic component 5-CQA on oncogenic Ras proteins

Palmioli, A
Co-primo
;
Ciaramelli, C
Co-primo
;
Tisi, R;Spinelli, M;De Sanctis, G;Sacco, E
;
Airoldi, C
Ultimo
2017

Abstract

Recent epidemiological studies have demonstrated that the consumption of healthy foods that are particularly rich in polyphenols might reduce the incidence of cancer and neurodegenerative diseases. In particular, chlorogenic acids (CGAs) occur ubiquitously in food and represent the most abundant polyphenols in the human diet. A number of beneficial biological effects of CGAs, such as anti-inflammatory activity, anti-carcinogenic activity, and protection against neurodegenerative diseases, have been reported. However, the molecular mechanisms at the base of these biological activities have not yet been investigated in depth. By combining NMR spectroscopy, molecular docking, surface plasmon resonance and ex vivo assays of the Ras-dependent breast cancer cell line MDA-MB-231, we contribute to the elucidation of the molecular basis of the activity of CGAs and natural extracts from green and roasted coffee beans as chemoprotective dietary supplements.
Articolo in rivista - Articolo scientifico
cancer prevention, chlorogenic acid, coffee extracts, NMR molecular recognition studies, Ras proteins
English
2017
12
18
2457
2466
partially_open
Palmioli, A., Ciaramelli, C., Tisi, R., Spinelli, M., De Sanctis, G., Sacco, E., et al. (2017). Natural compounds in cancer prevention: effects of coffee extracts and their main polyphenolic component 5-CQA on oncogenic Ras proteins. CHEMISTRY - AN ASIAN JOURNAL, 12(18), 2457-2466 [10.1002/asia.201700844].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/161161
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