COMMENTARY ON: Foxa1 and Foxa2 regulate bile duct development in mice. J Clin Invest 2009;119:1537-45. Journal of Clinical Investigation. Online by Li Z. et al. Copyright 2009 by American society for Clinical Investigation. Reprinted with permission of American Society for Clinical Investigation in the format Journal via Copyright Clearance Center. Abstract: The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental competence of the foregut endoderm and in initiating liver specification. Using conditional gene ablation during a later phase of liver development, we show here that deletion of both Foxa1 and Foxa2 (Foxa1/2) in the embryonic liver caused hyperplasia of the biliary tree. Abnormal bile duct formation in Foxa1/2-deficient liver was due, at least in part, to activation of IL-6 expression, a proliferative signal for cholangiocytes. The glucocorticoid receptor is a negative regulator of IL-6 transcription; in the absence of Foxa1/2, the glucocorticoid receptor failed to bind to the IL-6 promoter, causing enhanced IL-6 expression. Thus, after liver specification, Foxa1/2 are required for normal bile duct development through prevention of excess cholangiocyte proliferation. Our data suggest that Foxa1/2 function as terminators of bile duct expansion in the adult liver through inhibition of IL-6 expression. © 2010 European Association for the Study of the Liver.

Strazzabosco, M. (2010). Foxa1 and Foxa2 regulate bile duct development in mice. JOURNAL OF HEPATOLOGY, 52(5), 765-767 [10.1016/j.jhep.2009.12.022].

Foxa1 and Foxa2 regulate bile duct development in mice

STRAZZABOSCO, MARIO
2010

Abstract

COMMENTARY ON: Foxa1 and Foxa2 regulate bile duct development in mice. J Clin Invest 2009;119:1537-45. Journal of Clinical Investigation. Online by Li Z. et al. Copyright 2009 by American society for Clinical Investigation. Reprinted with permission of American Society for Clinical Investigation in the format Journal via Copyright Clearance Center. Abstract: The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental competence of the foregut endoderm and in initiating liver specification. Using conditional gene ablation during a later phase of liver development, we show here that deletion of both Foxa1 and Foxa2 (Foxa1/2) in the embryonic liver caused hyperplasia of the biliary tree. Abnormal bile duct formation in Foxa1/2-deficient liver was due, at least in part, to activation of IL-6 expression, a proliferative signal for cholangiocytes. The glucocorticoid receptor is a negative regulator of IL-6 transcription; in the absence of Foxa1/2, the glucocorticoid receptor failed to bind to the IL-6 promoter, causing enhanced IL-6 expression. Thus, after liver specification, Foxa1/2 are required for normal bile duct development through prevention of excess cholangiocyte proliferation. Our data suggest that Foxa1/2 function as terminators of bile duct expansion in the adult liver through inhibition of IL-6 expression. © 2010 European Association for the Study of the Liver.
Articolo in rivista - Articolo scientifico
Foxa1, Foxa2, bile ducts, development
English
2010
52
5
765
767
none
Strazzabosco, M. (2010). Foxa1 and Foxa2 regulate bile duct development in mice. JOURNAL OF HEPATOLOGY, 52(5), 765-767 [10.1016/j.jhep.2009.12.022].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/15905
Citazioni
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
Social impact