BCL10, a gene involved in apoptosis signalling, has recently been identified through the cloning of chromosomal breakpoints in extranodal (MALT-type) marginal zone lymphomas carrying the t(1;14)(p22;q32) translocation. BCL10 was also found mutated in these cases as well as in other types of lymphoid and solid tumors, suggesting that its inactivation may play an important pathogenetic role; however, this has been questioned by recent studies showing a lack of somatic mutations in human cancers. We report the mutation analysis of exons 1-3 of the BCL10 gene in DNAs from 228 cases of lymphoid malignancies (30 B cell chronic lymphocytic leukemias, 123 B and 45 T non-Hodgkin's lymphomas and 30 multiple myelomas). Somatic mutations were detected in four cases (2%): one small lymphocytic, one follicular and two diffuse large cell lymphomas. The mutations were all within exon 3 and have not been previously reported. Our data suggest that BCL10 mutations may play only a limited role in the pathogenesis of lymphoid neoplasms

Luminari, S., Intini, D., Baldini, L., Berti, E., Bertoni, F., Zucca, E., et al. (2000). BCL10 gene mutations rarely occur in lymphoid malignancies. LEUKEMIA, 14(5), 905-908 [10.1038/sj.leu.2401747].

BCL10 gene mutations rarely occur in lymphoid malignancies

BERTI, EMILIO;
2000

Abstract

BCL10, a gene involved in apoptosis signalling, has recently been identified through the cloning of chromosomal breakpoints in extranodal (MALT-type) marginal zone lymphomas carrying the t(1;14)(p22;q32) translocation. BCL10 was also found mutated in these cases as well as in other types of lymphoid and solid tumors, suggesting that its inactivation may play an important pathogenetic role; however, this has been questioned by recent studies showing a lack of somatic mutations in human cancers. We report the mutation analysis of exons 1-3 of the BCL10 gene in DNAs from 228 cases of lymphoid malignancies (30 B cell chronic lymphocytic leukemias, 123 B and 45 T non-Hodgkin's lymphomas and 30 multiple myelomas). Somatic mutations were detected in four cases (2%): one small lymphocytic, one follicular and two diffuse large cell lymphomas. The mutations were all within exon 3 and have not been previously reported. Our data suggest that BCL10 mutations may play only a limited role in the pathogenesis of lymphoid neoplasms
Articolo in rivista - Articolo scientifico
BCL10, Multiple myeloma, Mutation analysis, Non-Hodgkin's lymphoma
English
2000
14
5
905
908
none
Luminari, S., Intini, D., Baldini, L., Berti, E., Bertoni, F., Zucca, E., et al. (2000). BCL10 gene mutations rarely occur in lymphoid malignancies. LEUKEMIA, 14(5), 905-908 [10.1038/sj.leu.2401747].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/15822
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