The advent of safe and highly effective direct-acting antiviral agents (DAAs) has had huge implications for the hepatitis C virus (HCV) transplant field, and changed our management of both patients on the waiting list and those with HCV graft re-infection after liver transplantation (LT). When treating HCV infection before LT, HCV re-infection of the graft can be prevented in nearly all patients. In addition, some candidates show a remarkable clinical improvement and may be delisted. Alternatively, HCV infection can be treated post-LT either soon after the transplant, taking advantage of the removal of the infected native liver, or at the time of disease recurrence, as was carried out in the past. In either case, some DAAs have a limited use because of their drug to drug interactions with various immunosuppressants as well as the many other drugs liver transplant recipients are often prescribed. In addition, some DAAs should be avoided in case of severe renal failure, which is not an unusual complication after LT. The present document provides a series of consensus statements on the LT issues that have not been extensively addressed previously. These statements have been developed to support physicians and other stakeholders in charge of LT candidates and recipients when deciding to treat HCV, especially in difficult situations.

Belli, L., Duvoux, C., Berg, T., Strazzabosco, M., Fagiuoli, S., Khoo, S., et al. (2017). ELITA consensus statements on the use of DAAs in liver transplant candidates and recipients. JOURNAL OF HEPATOLOGY, 67(3), 585-602 [10.1016/j.jhep.2017.03.006].

ELITA consensus statements on the use of DAAs in liver transplant candidates and recipients

STRAZZABOSCO, MARIO;Fagiuoli, S;Puoti, M;
2017

Abstract

The advent of safe and highly effective direct-acting antiviral agents (DAAs) has had huge implications for the hepatitis C virus (HCV) transplant field, and changed our management of both patients on the waiting list and those with HCV graft re-infection after liver transplantation (LT). When treating HCV infection before LT, HCV re-infection of the graft can be prevented in nearly all patients. In addition, some candidates show a remarkable clinical improvement and may be delisted. Alternatively, HCV infection can be treated post-LT either soon after the transplant, taking advantage of the removal of the infected native liver, or at the time of disease recurrence, as was carried out in the past. In either case, some DAAs have a limited use because of their drug to drug interactions with various immunosuppressants as well as the many other drugs liver transplant recipients are often prescribed. In addition, some DAAs should be avoided in case of severe renal failure, which is not an unusual complication after LT. The present document provides a series of consensus statements on the LT issues that have not been extensively addressed previously. These statements have been developed to support physicians and other stakeholders in charge of LT candidates and recipients when deciding to treat HCV, especially in difficult situations.
Articolo in rivista - Review Essay
Antiviral agents; Guidelines; Hepatitis C, chronic; Interferons; Liver failure; Liver transplant candidate; Liver transplant recipient; Liver transplantation; Recurrent hepatitis C; Waiting lists;
Direct Antiviral Agents; Liver Transplant Candidate; Liver Transplant Recipient; Liver Transplantation; Recurrent hepatitis C
English
8-mar-2017
2017
67
3
585
602
none
Belli, L., Duvoux, C., Berg, T., Strazzabosco, M., Fagiuoli, S., Khoo, S., et al. (2017). ELITA consensus statements on the use of DAAs in liver transplant candidates and recipients. JOURNAL OF HEPATOLOGY, 67(3), 585-602 [10.1016/j.jhep.2017.03.006].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/151682
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