In this review we have summarized the known virulent factors of P. aeruginosa in the development of ventilator associated pneumonia (VAP). This gram negative rod bacterium colonizes through several pathogenic mechanisms that can be summarized as follows: 1) cell surface virulence factors; 2) secreted virulence factors; 3) type secretion system; 4) quorum sensing. Another additional aspect that is covered is the capacity of P. aeruginosa of organized growth as a biofilm, which is a particular growth pattern in which bacteria gain high levels of antimicrobial resistance. The development of new antimicrobial strategies may use this understanding of the bacterium behavior for possible prevention, or eradication of the infective agent, in case of severe infections. © 2013 Bentham Science Publishers.

Introna, M., Pinciroli, R., Bittner, E., Berra, L. (2013). Recent Findings Regarding Pathogenesis and Prevention of Ventilator-Associated Pneumonia. CURRENT RESPIRATORY MEDICINE REVIEWS, 9(1), 26-33 [10.2174/1573398X11309010004].

Recent Findings Regarding Pathogenesis and Prevention of Ventilator-Associated Pneumonia

PINCIROLI, RICCARDO
Secondo
;
BERRA, LORENZO
Ultimo
2013

Abstract

In this review we have summarized the known virulent factors of P. aeruginosa in the development of ventilator associated pneumonia (VAP). This gram negative rod bacterium colonizes through several pathogenic mechanisms that can be summarized as follows: 1) cell surface virulence factors; 2) secreted virulence factors; 3) type secretion system; 4) quorum sensing. Another additional aspect that is covered is the capacity of P. aeruginosa of organized growth as a biofilm, which is a particular growth pattern in which bacteria gain high levels of antimicrobial resistance. The development of new antimicrobial strategies may use this understanding of the bacterium behavior for possible prevention, or eradication of the infective agent, in case of severe infections. © 2013 Bentham Science Publishers.
Articolo in rivista - Articolo scientifico
VAP (ventilator-associated pneumonia)
English
2013
9
1
26
33
none
Introna, M., Pinciroli, R., Bittner, E., Berra, L. (2013). Recent Findings Regarding Pathogenesis and Prevention of Ventilator-Associated Pneumonia. CURRENT RESPIRATORY MEDICINE REVIEWS, 9(1), 26-33 [10.2174/1573398X11309010004].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/146720
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
Social impact