OBJECTIVES: : To identify independent predictors of adverse neonatal outcome in cases of fetal growth restriction (FGR) at >/=34 weeks. METHODS: : From a cohort of 481 FGR cases delivered at >/=34 weeks, demographic and obstetrical variables, fetal biometry, Doppler indices at uterine, umbilical and middle cerebral arteries available within 2 weeks of delivery, were related to adverse neonatal outcome, defined as admission to the neonatal intensive care unit (NICU) for indications other than low birth weight alone. RESULTS: : Logistic regression analysis showed that gestational age (GA) at delivery (OR =0.59, 95% CI 0.50-0.70), abdominal circumference (AC) centile (OR = 0.69, 95% CI 0.59-0.81), and umbilical artery (UA) pulsatility index (PI) centile (OR = 1.02, 95% CI 1.01-1.04) significantly correlated with adverse neonatal outcome. From this model we calculated a score of adverse neonatal outcome expressed by the formula: (UA PI centile/3)-(10*AC centile)+[10*(40-GA at delivery)]. Receiver operating characteristic (ROC) curve analysis demonstrated that a score >/=25 optimally predicted adverse neonatal outcome (sensitivity of 75%, false positive rate of 25%). A GA at delivery >37.5 weeks optimally predicts adverse outcome independently from AC centile or UA PI centile. CONCLUSION: : In late preterm or term FGR, GA at delivery is the most important predictor of adverse neonatal outcome. At >37.5 weeks, delivery may be the best option to minimize adverse outcome in all FGR cases. At 34-37 weeks, a score based on GA at delivery, UA PI centile, and AC centile optimally predicts adverse neonatal outcome. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd.

Vergani, P., Roncaglia, N., Ghidini, A., Crippa, I., Andreotti, C., Sala, F., et al. (2006). Can we predict adverse neonatal outcome in fetal growth restriction near term?. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 195(6), S206-S206 [10.1016/j.ajog.2006.10.740].

Can we predict adverse neonatal outcome in fetal growth restriction near term?

VERGANI, PATRIZIA;
2006

Abstract

OBJECTIVES: : To identify independent predictors of adverse neonatal outcome in cases of fetal growth restriction (FGR) at >/=34 weeks. METHODS: : From a cohort of 481 FGR cases delivered at >/=34 weeks, demographic and obstetrical variables, fetal biometry, Doppler indices at uterine, umbilical and middle cerebral arteries available within 2 weeks of delivery, were related to adverse neonatal outcome, defined as admission to the neonatal intensive care unit (NICU) for indications other than low birth weight alone. RESULTS: : Logistic regression analysis showed that gestational age (GA) at delivery (OR =0.59, 95% CI 0.50-0.70), abdominal circumference (AC) centile (OR = 0.69, 95% CI 0.59-0.81), and umbilical artery (UA) pulsatility index (PI) centile (OR = 1.02, 95% CI 1.01-1.04) significantly correlated with adverse neonatal outcome. From this model we calculated a score of adverse neonatal outcome expressed by the formula: (UA PI centile/3)-(10*AC centile)+[10*(40-GA at delivery)]. Receiver operating characteristic (ROC) curve analysis demonstrated that a score >/=25 optimally predicted adverse neonatal outcome (sensitivity of 75%, false positive rate of 25%). A GA at delivery >37.5 weeks optimally predicts adverse outcome independently from AC centile or UA PI centile. CONCLUSION: : In late preterm or term FGR, GA at delivery is the most important predictor of adverse neonatal outcome. At >37.5 weeks, delivery may be the best option to minimize adverse outcome in all FGR cases. At 34-37 weeks, a score based on GA at delivery, UA PI centile, and AC centile optimally predicts adverse neonatal outcome. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd.
Articolo in rivista - Articolo scientifico
fetal growth restriction, umbilical artery Doppler, uterine artery Doppler, fetal biometry
English
2006
195
6
S206
S206
none
Vergani, P., Roncaglia, N., Ghidini, A., Crippa, I., Andreotti, C., Sala, F., et al. (2006). Can we predict adverse neonatal outcome in fetal growth restriction near term?. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 195(6), S206-S206 [10.1016/j.ajog.2006.10.740].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14629
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