The aim of the present study is to support the safety and feasibility of chemo-conization for early-stage cervical tumor in young patients wishing to preserve their fertility. METHODS: Between October 2004 and November 2006, eleven patients were scheduled for conservative treatment. Subjects were selected for this treatment on the basis of favorable cervical tumors (<3 cm) and a desire to maintain fertility. All patients underwent neoadjuvant chemotherapy followed by conization or conization alone with pelvic lymphadenectomy. Obstetrical and oncologic outcomes were evaluated. RESULTS AND CONCLUSIONS: The mean age of the eleven patients was 32 (range: 24-41), Figo Stage was IB1 in 8 cases and 3 cases were Stage IA2. Histological findings were squamous cell carcinoma in 5 patients and adenocarcinoma in 6 patients. Two patients were treated with TEP regimen every 3 weeks for three courses, while one patient had adjuvant chemotherapy with TEP. No recurrences were observed after a median follow-up of 20 months (range 7-29 months). Three pregnancies occurred during the follow-up period. Although the number is small, in selected patients this conservative approach seems to be feasible to cure early-stage cervical cancer therefore maintaining fertility.

Landoni, F., Parma, G., Peiretti, M., Zanagnolo, V., Sideri, M., Colombo, N., et al. (2007). Chemo-conization in early cervical cancer. GYNECOLOGIC ONCOLOGY, 107(1), 125-126 [10.1016/j.ygyno.2007.07.011].

Chemo-conization in early cervical cancer

Landoni, F;COLOMBO, NICOLETTA;
2007

Abstract

The aim of the present study is to support the safety and feasibility of chemo-conization for early-stage cervical tumor in young patients wishing to preserve their fertility. METHODS: Between October 2004 and November 2006, eleven patients were scheduled for conservative treatment. Subjects were selected for this treatment on the basis of favorable cervical tumors (<3 cm) and a desire to maintain fertility. All patients underwent neoadjuvant chemotherapy followed by conization or conization alone with pelvic lymphadenectomy. Obstetrical and oncologic outcomes were evaluated. RESULTS AND CONCLUSIONS: The mean age of the eleven patients was 32 (range: 24-41), Figo Stage was IB1 in 8 cases and 3 cases were Stage IA2. Histological findings were squamous cell carcinoma in 5 patients and adenocarcinoma in 6 patients. Two patients were treated with TEP regimen every 3 weeks for three courses, while one patient had adjuvant chemotherapy with TEP. No recurrences were observed after a median follow-up of 20 months (range 7-29 months). Three pregnancies occurred during the follow-up period. Although the number is small, in selected patients this conservative approach seems to be feasible to cure early-stage cervical cancer therefore maintaining fertility.
Articolo in rivista - Articolo scientifico
Cervical cancer; Fertility presentation; Chemo-conization
English
ott-2007
107
1
125
126
none
Landoni, F., Parma, G., Peiretti, M., Zanagnolo, V., Sideri, M., Colombo, N., et al. (2007). Chemo-conization in early cervical cancer. GYNECOLOGIC ONCOLOGY, 107(1), 125-126 [10.1016/j.ygyno.2007.07.011].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14418
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