This review illustrates promising regenerative medicine technologies that are being developed for the treatment of gastrointestinal diseases. The main strategies under validation to bioengineer or regenerate liver, pancreas, or parts of the digestive tract are twofold: engineering of progenitor cells and seeding of cells on supporting scaffold material. In the first case, stem cells are initially expanded under standard tissue culture conditions. Thereafter, these cells may either be delivered directly to the tissue or organ of interest, or they may be loaded onto a synthetic or natural three-dimensional scaffold that is capable of enhancing cell viability and function. The new construct harbouring the cells usually undergoes a maturation phase within a bioreactor. Within the bioreactor, cells are conditioned to adopt a phenotype similar to that displayed in the native organ. The specific nature of the scaffold within the bioreactor is critical for the development of this high-function phenotype. Efforts to bioengineer or regenerate gastrointestinal tract, liver and pancreas have yielded promising results and have demonstrated the immense potential of regenerative medicine. However, a myriad of technical hurdles must be overcome before transplantable, engineered organs become a reality.

Orlando, G., Bendala, J., Shupe, T., Bergman, C., Bitar, K., Booth, C., et al. (2013). Cell and organ bioengineering technology as applied to gastrointestinal diseases. GUT, 62(5), 774-786 [10.1136/gutjnl-2011-301111].

Cell and organ bioengineering technology as applied to gastrointestinal diseases

CARBONE, MARCO;
2013

Abstract

This review illustrates promising regenerative medicine technologies that are being developed for the treatment of gastrointestinal diseases. The main strategies under validation to bioengineer or regenerate liver, pancreas, or parts of the digestive tract are twofold: engineering of progenitor cells and seeding of cells on supporting scaffold material. In the first case, stem cells are initially expanded under standard tissue culture conditions. Thereafter, these cells may either be delivered directly to the tissue or organ of interest, or they may be loaded onto a synthetic or natural three-dimensional scaffold that is capable of enhancing cell viability and function. The new construct harbouring the cells usually undergoes a maturation phase within a bioreactor. Within the bioreactor, cells are conditioned to adopt a phenotype similar to that displayed in the native organ. The specific nature of the scaffold within the bioreactor is critical for the development of this high-function phenotype. Efforts to bioengineer or regenerate gastrointestinal tract, liver and pancreas have yielded promising results and have demonstrated the immense potential of regenerative medicine. However, a myriad of technical hurdles must be overcome before transplantable, engineered organs become a reality.
Articolo in rivista - Articolo scientifico
Bioengineering; Gastrointestinal Diseases; Humans; Intestinal Diseases; Liver Failure; Liver Regeneration; Liver Transplantation; Organ Transplantation; Pancreatic Diseases; Tissue Engineering; Tissue Scaffolds; Regenerative Medicine; Stem Cell Transplantation; Gastroenterology
English
2013
GUT
62
5
774
786
none
Orlando, G., Bendala, J., Shupe, T., Bergman, C., Bitar, K., Booth, C., et al. (2013). Cell and organ bioengineering technology as applied to gastrointestinal diseases. GUT, 62(5), 774-786 [10.1136/gutjnl-2011-301111].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/141294
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