Treatment of hematologic disorders in low-income countries (LIC) is difficult. This report summarizes treatment of sickle cell disease and aplastic anemia by pediatric hematologists from 15 LIC who participate in the Monza International School of Pediatric Hematology/Oncology (MISPHO). Patients with severe sickle cell disease were treated with low dose hydroxyurea, which safely reduced vaso-occlusive crises. Patients with severe aplastic anemia fared poorly due to lack of availability and high cost of anti-thymocyte globulin and cyclosporine and lack of access to stem cell transplantation. Appropriate therapy was most likely to occur in MISPHO centers with an active twinning program with a center in a high-income country.

Howard, S., Wilimas, J., Flores, A., Pacheco, C., de Reyes, G., Machin, S., et al. (2007). Treatment for children with severe aplastic anemia and sickle cell disease in low income countries in Latin America: a report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO): Part III. PEDIATRIC BLOOD & CANCER, 48(5), 598-599 [10.1002/pbc.20988].

Treatment for children with severe aplastic anemia and sickle cell disease in low income countries in Latin America: a report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO): Part III

MASERA, GIUSEPPE
2007

Abstract

Treatment of hematologic disorders in low-income countries (LIC) is difficult. This report summarizes treatment of sickle cell disease and aplastic anemia by pediatric hematologists from 15 LIC who participate in the Monza International School of Pediatric Hematology/Oncology (MISPHO). Patients with severe sickle cell disease were treated with low dose hydroxyurea, which safely reduced vaso-occlusive crises. Patients with severe aplastic anemia fared poorly due to lack of availability and high cost of anti-thymocyte globulin and cyclosporine and lack of access to stem cell transplantation. Appropriate therapy was most likely to occur in MISPHO centers with an active twinning program with a center in a high-income country.
Articolo in rivista - Articolo scientifico
Latin America; Anemia, Sickle Cell; Anemia, Aplastic; Developing Countries; Cyclosporine; Child; Hydroxyurea; Antilymphocyte Serum; International Cooperation; Humans
English
2007
48
5
598
599
none
Howard, S., Wilimas, J., Flores, A., Pacheco, C., de Reyes, G., Machin, S., et al. (2007). Treatment for children with severe aplastic anemia and sickle cell disease in low income countries in Latin America: a report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO): Part III. PEDIATRIC BLOOD & CANCER, 48(5), 598-599 [10.1002/pbc.20988].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14112
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